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- NCIT_C123902 IAO_0000115 "An orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9), with potential antineoplastic and chemoprotective activities. Upon oral administration, fadraciclib selectively binds to and inhibits the activity of CDK2, 5 and 9, which leads to inhibition of CDK2, 5 and 9-dependent cellular pathways, downregulation of genes involved in the pro-survival pathway, prevention of the activation of DNA double-strand break repair pathways, and induction of both cell cycle arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing tumor cells. In addition, CYC065 protects hematopoietic stem and progenitor cells (HSPCs), prevents myelosuppression, and preserves the function of the bone marrow. CDKs are serine/threonine kinases involved in the regulation of the cell cycle and may be overexpressed in certain cancer cell types; they play key roles in tumor cell proliferation, the regulation of transcription, and DNA damage repair." @default.
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- NCIT_C123902 NCIT_P106 "Organic Chemical" @default.
- NCIT_C123902 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123902 NCIT_P107 "Fadraciclib" @default.
- NCIT_C123902 NCIT_P108 "Fadraciclib" @default.
- NCIT_C123902 NCIT_P208 "CL498266" @default.
- NCIT_C123902 NCIT_P210 "1070790-89-4" @default.
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- NCIT_C123902 NCIT_P330 "775991" @default.
- NCIT_C123902 NCIT_P375 "CDK2/5/9 Inhibitor CYC065" @default.
- NCIT_C123902 NCIT_P375 "Fadraciclib" @default.
- NCIT_C123902 NCIT_P399 "775991" @default.
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- NCIT_C123902 normalizedInformationContent "100" @default.
- NCIT_C123902 referenceCount "1" @default.
- NCIT_C123902 hasExactSynonym "CYC065" @default.
- NCIT_C123902 hasExactSynonym "Cyclin Dependent Kinase Inhibitor 2/5/9 CYC065" @default.
- NCIT_C123902 hasExactSynonym "FADRACICLIB" @default.
- NCIT_C123902 hasExactSynonym "Fadraciclib" @default.
- NCIT_C123902 inSubset NCIT_C116977 @default.
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- NCIT_C123902 type Class @default.
- NCIT_C123902 isDefinedBy ncit.owl @default.
- NCIT_C123902 label "Fadraciclib" @default.
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