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- NCIT_C123921 IAO_0000115 "A dendritic cell (DC)-based vaccine composed of program death ligands 1 and 2 (PDL1/L2)-silenced DCs and loaded with the recipient's minor histocompatibility antigens (MiHA), with potential use for graft-versus-tumor (GVT) induction following allogeneic stem cell transplantation (allo-SCT). Donor DCs are electroporated ex vivo with MiHA mRNA and small interfering RNAs (siRNAs) designed to silence the expression of PD L1/L2. After allo-SCT and upon intravenous administration of the MiHA-loaded PD-L1/L2-silenced DC vaccine, the DCs induce the expansion and activation of MiHA-specific CD8-positive T-cells. These tumor antigen-reactive T-cells exert their GVT effect by killing miHA-positive tumor cells. PD-L1/L2, co-inhibitory ligands expressed on DCs, play key roles in preventing MiHA-specific CD8-positive T-cell expansion; silencing enhances MiHA-specific CD8-positive T-cell expansion and activity and improves the GVT effect. The MiHA are human leukocyte antigen (HLA)-bound peptides and are exclusively expressed by the recipient's hematopoietic tumor cells." @default.
- NCIT_C123921 NCIT_NHC0 "C123921" @default.
- NCIT_C123921 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C123921 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123921 NCIT_P108 "MiHA-loaded PD-L1/L2-silenced Dendritic Cell Vaccine" @default.
- NCIT_C123921 NCIT_P208 "CL498285" @default.
- NCIT_C123921 NCIT_P329 "775894" @default.
- NCIT_C123921 NCIT_P330 "775894" @default.
- NCIT_C123921 NCIT_P399 "775894" @default.
- NCIT_C123921 normalizedInformationContent "100" @default.
- NCIT_C123921 referenceCount "1" @default.
- NCIT_C123921 hasExactSynonym "MiHA-loaded PD-L-silenced DC Vaccine" @default.
- NCIT_C123921 hasExactSynonym "MiHA-loaded PD-L1/L2-silenced Dendritic Cell Vaccine" @default.
- NCIT_C123921 inSubset NCIT_C128784 @default.
- NCIT_C123921 inSubset NCIT_C176424 @default.
- NCIT_C123921 type Class @default.
- NCIT_C123921 isDefinedBy ncit.owl @default.
- NCIT_C123921 label "MiHA-loaded PD-L1/L2-silenced Dendritic Cell Vaccine" @default.
- NCIT_C123921 subClassOf NCIT_C123921 @default.
- NCIT_C123921 subClassOf NCIT_C129820 @default.
- NCIT_C123921 subClassOf NCIT_C1663 @default.
- NCIT_C123921 subClassOf NCIT_C1908 @default.
- NCIT_C123921 subClassOf NCIT_C1909 @default.
- NCIT_C123921 subClassOf NCIT_C274 @default.
- NCIT_C123921 subClassOf NCIT_C28308 @default.
- NCIT_C123921 subClassOf NCIT_C28310 @default.
- NCIT_C123921 subClassOf NCIT_C307 @default.
- NCIT_C123921 subClassOf NCIT_C308 @default.
- NCIT_C123921 subClassOf NCIT_C923 @default.