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- NCIT_C123923 IAO_0000115 "A therapeutic DNA vaccine composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), the second is a dimerization entity and the third part encodes a protein that specifically binds to antigen presenting cells (APCs), with potential immunostimulating and antineoplastic activities. Upon intramuscular administration, the DNA vaccine VB10.16 expresses HPV16 E6/7 and a protein that targets receptors on APCs. Upon binding to APCs and subsequent internalization, the APCs mature and the HPV16 E6/7 antigenic protein is presented by the APCs. This attracts and stimulates B-lymphocytes, CD4-positive T-lymphocytes and elicits a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing HPV16-associated E6 and E7 oncoproteins, which result in tumor cell lysis. HPV16 E6/7, a viral antigen, plays a key role in the development of certain types of cancer." @default.
- NCIT_C123923 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123923 NCIT_NHC0 "C123923" @default.
- NCIT_C123923 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123923 NCIT_P108 "DNA Vaccine VB10.16" @default.
- NCIT_C123923 NCIT_P208 "CL498287" @default.
- NCIT_C123923 NCIT_P322 "GDC" @default.
- NCIT_C123923 NCIT_P329 "775928" @default.
- NCIT_C123923 NCIT_P330 "775928" @default.
- NCIT_C123923 NCIT_P375 "DNA Vaccine VB10.16" @default.
- NCIT_C123923 NCIT_P399 "775928" @default.
- NCIT_C123923 normalizedInformationContent "100" @default.
- NCIT_C123923 referenceCount "1" @default.
- NCIT_C123923 hasExactSynonym "DNA Vaccine VB10.16" @default.
- NCIT_C123923 hasExactSynonym "VB10.16 Vaccine" @default.
- NCIT_C123923 hasExactSynonym "VB10.16" @default.
- NCIT_C123923 inSubset NCIT_C128784 @default.
- NCIT_C123923 inSubset NCIT_C157711 @default.
- NCIT_C123923 inSubset NCIT_C157712 @default.
- NCIT_C123923 inSubset NCIT_C176424 @default.
- NCIT_C123923 inSubset NCIT_C177537 @default.
- NCIT_C123923 type Class @default.
- NCIT_C123923 isDefinedBy ncit.owl @default.
- NCIT_C123923 label "DNA Vaccine VB10.16" @default.
- NCIT_C123923 subClassOf NCIT_C123923 @default.
- NCIT_C123923 subClassOf NCIT_C129820 @default.
- NCIT_C123923 subClassOf NCIT_C1663 @default.
- NCIT_C123923 subClassOf NCIT_C1908 @default.
- NCIT_C123923 subClassOf NCIT_C1909 @default.
- NCIT_C123923 subClassOf NCIT_C274 @default.
- NCIT_C123923 subClassOf NCIT_C307 @default.
- NCIT_C123923 subClassOf NCIT_C308 @default.
- NCIT_C123923 subClassOf NCIT_C39619 @default.
- NCIT_C123923 subClassOf NCIT_C923 @default.