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- NCIT_C123925 IAO_0000115 "An orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, zandelisib selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival." @default.
- NCIT_C123925 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123925 NCIT_A7 NCIT_C113631 @default.
- NCIT_C123925 NCIT_NHC0 "C123925" @default.
- NCIT_C123925 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123925 NCIT_P107 "Zandelisib" @default.
- NCIT_C123925 NCIT_P108 "Zandelisib" @default.
- NCIT_C123925 NCIT_P208 "CL498289" @default.
- NCIT_C123925 NCIT_P210 "1401436-95-0" @default.
- NCIT_C123925 NCIT_P319 "8Z28M5SX0X" @default.
- NCIT_C123925 NCIT_P322 "CTRP" @default.
- NCIT_C123925 NCIT_P322 "FDA" @default.
- NCIT_C123925 NCIT_P322 "GDC" @default.
- NCIT_C123925 NCIT_P329 "775930" @default.
- NCIT_C123925 NCIT_P330 "775930" @default.
- NCIT_C123925 NCIT_P375 "PI3K-delta Inhibitor PWT143" @default.
- NCIT_C123925 NCIT_P375 "Zandelisib" @default.
- NCIT_C123925 NCIT_P399 "775930" @default.
- NCIT_C123925 normalizedInformationContent "100" @default.
- NCIT_C123925 referenceCount "1" @default.
- NCIT_C123925 hasExactSynonym "ME 401" @default.
- NCIT_C123925 hasExactSynonym "ME-401" @default.
- NCIT_C123925 hasExactSynonym "PI3K-delta Inhibitor PWT143" @default.
- NCIT_C123925 hasExactSynonym "PWT-143" @default.
- NCIT_C123925 hasExactSynonym "PWT143" @default.
- NCIT_C123925 hasExactSynonym "ZANDELISIB" @default.
- NCIT_C123925 hasExactSynonym "Zandelisib" @default.
- NCIT_C123925 inSubset NCIT_C116977 @default.
- NCIT_C123925 inSubset NCIT_C116978 @default.
- NCIT_C123925 inSubset NCIT_C128784 @default.
- NCIT_C123925 inSubset NCIT_C157711 @default.
- NCIT_C123925 inSubset NCIT_C157712 @default.
- NCIT_C123925 inSubset NCIT_C176424 @default.
- NCIT_C123925 inSubset NCIT_C177537 @default.
- NCIT_C123925 inSubset NCIT_C63923 @default.
- NCIT_C123925 type Class @default.
- NCIT_C123925 isDefinedBy ncit.owl @default.
- NCIT_C123925 label "Zandelisib" @default.
- NCIT_C123925 subClassOf NCIT_C123925 @default.
- NCIT_C123925 subClassOf NCIT_C129824 @default.
- NCIT_C123925 subClassOf NCIT_C129825 @default.
- NCIT_C123925 subClassOf NCIT_C1404 @default.
- NCIT_C123925 subClassOf NCIT_C163758 @default.
- NCIT_C123925 subClassOf NCIT_C1742 @default.
- NCIT_C123925 subClassOf NCIT_C1908 @default.
- NCIT_C123925 subClassOf NCIT_C1909 @default.
- NCIT_C123925 subClassOf NCIT_C2152 @default.
- NCIT_C123925 subClassOf NCIT_C2189 @default.
- NCIT_C123925 subClassOf NCIT_C274 @default.
- NCIT_C123925 subClassOf NCIT_C471 @default.