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- NCIT_C123928 IAO_0000115 "A therapeutic interleukin-12 (IL-12)-expressing dendritic cell (DC)-based vaccine composed of autologous monocyte-derived DCs loaded with autologous tumor cell lysate and exposed to the microbial cell wall component lipopolysaccharide (LPS), with potential immunomodulating and antineoplastic activities. The monocyte-derived immature DCs are loaded with autologous tumor cell lysates and are subsequently exposed to LPS and interferon-gamma (IFN-gamma). Upon administration of audencel, the mature DCs migrate into the lymph nodes, express the immune stimulatory cytokine interleukin-12 (IL-12) and activate the immune system by promoting the activation of natural killer (NK) cells and induce a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation. Exposure to LPS and IFN-gamma allows the maturation of DCs and optimizes the presentation of tumor-associated antigens (TAAs) by DCs to T-lymphocytes." @default.
- NCIT_C123928 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123928 NCIT_NHC0 "C123928" @default.
- NCIT_C123928 NCIT_P106 "Cell" @default.
- NCIT_C123928 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123928 NCIT_P108 "Audencel" @default.
- NCIT_C123928 NCIT_P208 "CL498291" @default.
- NCIT_C123928 NCIT_P319 "H2CDQ1PWN7" @default.
- NCIT_C123928 NCIT_P322 "FDA" @default.
- NCIT_C123928 NCIT_P322 "GDC" @default.
- NCIT_C123928 NCIT_P329 "775935" @default.
- NCIT_C123928 NCIT_P330 "775935" @default.
- NCIT_C123928 NCIT_P375 "Audencel" @default.
- NCIT_C123928 NCIT_P375 "Autologous Dendritic Cell-based Immunotherapeutic AV0113" @default.
- NCIT_C123928 NCIT_P399 "775935" @default.
- NCIT_C123928 normalizedInformationContent "100" @default.
- NCIT_C123928 referenceCount "1" @default.
- NCIT_C123928 hasExactSynonym "AUDENCEL" @default.
- NCIT_C123928 hasExactSynonym "AV0113 DC-CIT" @default.
- NCIT_C123928 hasExactSynonym "AV0113 Dendritic Cell Cancer Immunotherapeutic" @default.
- NCIT_C123928 hasExactSynonym "AV0113" @default.
- NCIT_C123928 hasExactSynonym "Audencel" @default.
- NCIT_C123928 hasExactSynonym "Autologous DC-based Immunotherapeutic AV0113" @default.
- NCIT_C123928 inSubset NCIT_C128784 @default.
- NCIT_C123928 inSubset NCIT_C157711 @default.
- NCIT_C123928 inSubset NCIT_C157712 @default.
- NCIT_C123928 inSubset NCIT_C176424 @default.
- NCIT_C123928 inSubset NCIT_C177537 @default.
- NCIT_C123928 inSubset NCIT_C63923 @default.
- NCIT_C123928 type Class @default.
- NCIT_C123928 isDefinedBy ncit.owl @default.
- NCIT_C123928 label "Audencel" @default.
- NCIT_C123928 subClassOf NCIT_C123928 @default.
- NCIT_C123928 subClassOf NCIT_C129820 @default.
- NCIT_C123928 subClassOf NCIT_C129821 @default.
- NCIT_C123928 subClassOf NCIT_C129826 @default.
- NCIT_C123928 subClassOf NCIT_C142078 @default.
- NCIT_C123928 subClassOf NCIT_C1663 @default.
- NCIT_C123928 subClassOf NCIT_C1908 @default.
- NCIT_C123928 subClassOf NCIT_C1909 @default.
- NCIT_C123928 subClassOf NCIT_C274 @default.
- NCIT_C123928 subClassOf NCIT_C28308 @default.
- NCIT_C123928 subClassOf NCIT_C28310 @default.
- NCIT_C123928 subClassOf NCIT_C307 @default.
- NCIT_C123928 subClassOf NCIT_C308 @default.
- NCIT_C123928 subClassOf NCIT_C923 @default.