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- NCIT_C1244 IAO_0000115 "A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. (NCI04)" @default.
- NCIT_C1244 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1244 NCIT_NHC0 "C1244" @default.
- NCIT_C1244 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1244 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1244 NCIT_P107 "Temozolomide" @default.
- NCIT_C1244 NCIT_P108 "Temozolomide" @default.
- NCIT_C1244 NCIT_P175 "362856" @default.
- NCIT_C1244 NCIT_P207 "C0076080" @default.
- NCIT_C1244 NCIT_P210 "85622-93-1" @default.
- NCIT_C1244 NCIT_P302 "Malignant glioma (Anaplastic astrocytoma; Anaplastic oligodendrogliomas; Anaplastic oligoastrocytomas; Glioblastoma multiforme); Metastatic melanoma" @default.
- NCIT_C1244 NCIT_P319 "YF1K15M17Y" @default.
- NCIT_C1244 NCIT_P322 "CTRP" @default.
- NCIT_C1244 NCIT_P322 "FDA" @default.
- NCIT_C1244 NCIT_P322 "GDC" @default.
- NCIT_C1244 NCIT_P325 "A drug that is used to treat certain types of brain tumors in adults and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents." @default.
- NCIT_C1244 NCIT_P329 "41671" @default.
- NCIT_C1244 NCIT_P330 "41671" @default.
- NCIT_C1244 NCIT_P350 "C6H6N6O2" @default.
- NCIT_C1244 NCIT_P366 "Temozolomide" @default.
- NCIT_C1244 NCIT_P375 "Temozolomide" @default.
- NCIT_C1244 NCIT_P399 "41671" @default.
- NCIT_C1244 NCIT_R124 NCIT_C16507 @default.
- NCIT_C1244 NCIT_R124 NCIT_C16956 @default.
- NCIT_C1244 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1244 NCIT_R124 NCIT_C18264 @default.
- NCIT_C1244 NCIT_R124 NCIT_C19154 @default.
- NCIT_C1244 NCIT_R124 NCIT_C25825 @default.
- NCIT_C1244 NCIT_R124 NCIT_C25826 @default.
- NCIT_C1244 NCIT_R125 NCIT_C16514 @default.
- NCIT_C1244 NCIT_R125 NCIT_C17710 @default.
- NCIT_C1244 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1244 NCIT_R125 NCIT_C19152 @default.
- NCIT_C1244 NCIT_R125 NCIT_C21068 @default.
- NCIT_C1244 NCIT_R125 NCIT_C21069 @default.
- NCIT_C1244 NCIT_R125 NCIT_C21080 @default.
- NCIT_C1244 NCIT_R125 NCIT_C28498 @default.
- NCIT_C1244 NCIT_R125 NCIT_C40828 @default.
- NCIT_C1244 NCIT_R125 NCIT_C41543 @default.
- NCIT_C1244 NCIT_R125 NCIT_C41568 @default.
- NCIT_C1244 normalizedInformationContent "76.287274181997702" @default.
- NCIT_C1244 referenceCount "36" @default.
- NCIT_C1244 hasExactSynonym "3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide" @default.
- NCIT_C1244 hasExactSynonym "8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one" @default.
- NCIT_C1244 hasExactSynonym "CCRG-81045" @default.
- NCIT_C1244 hasExactSynonym "Gliotem" @default.
- NCIT_C1244 hasExactSynonym "Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-" @default.
- NCIT_C1244 hasExactSynonym "M & B 39831" @default.
- NCIT_C1244 hasExactSynonym "M and B 39831" @default.
- NCIT_C1244 hasExactSynonym "Methazolastone" @default.
- NCIT_C1244 hasExactSynonym "RP-46161" @default.
- NCIT_C1244 hasExactSynonym "SCH 52365" @default.
- NCIT_C1244 hasExactSynonym "TEMOZOLOMIDE" @default.
- NCIT_C1244 hasExactSynonym "TMZ" @default.
- NCIT_C1244 hasExactSynonym "Temcad" @default.
- NCIT_C1244 hasExactSynonym "Temizole" @default.
- NCIT_C1244 hasExactSynonym "Temodal" @default.
- NCIT_C1244 hasExactSynonym "Temodar" @default.
- NCIT_C1244 hasExactSynonym "Temomedac" @default.
- NCIT_C1244 hasExactSynonym "Temozolomide" @default.
- NCIT_C1244 hasExactSynonym "imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-" @default.
- NCIT_C1244 hasExactSynonym "temozolomide" @default.
- NCIT_C1244 inSubset NCIT_C116977 @default.
- NCIT_C1244 inSubset NCIT_C116978 @default.
- NCIT_C1244 inSubset NCIT_C128784 @default.
- NCIT_C1244 inSubset NCIT_C157711 @default.
- NCIT_C1244 inSubset NCIT_C157712 @default.
- NCIT_C1244 inSubset NCIT_C176424 @default.
- NCIT_C1244 inSubset NCIT_C177537 @default.
- NCIT_C1244 inSubset NCIT_C63923 @default.
- NCIT_C1244 type Class @default.
- NCIT_C1244 isDefinedBy ncit.owl @default.
- NCIT_C1244 label "Temozolomide" @default.
- NCIT_C1244 subClassOf B23a60fdef077cbfe7aa32f5aa282d5b2 @default.
- NCIT_C1244 subClassOf B2a5fd052b30ec1ef9652127da1cb45c9 @default.
- NCIT_C1244 subClassOf B5c239bd4a01270aabde93da9faf3b3e4 @default.
- NCIT_C1244 subClassOf B66b11317ebf16b3c63727bfc12c6a68f @default.
- NCIT_C1244 subClassOf B9e9c29e886358878b55546c5aa2fef4f @default.
- NCIT_C1244 subClassOf Bd5e98dc0ef250539e94879932135f49d @default.
- NCIT_C1244 subClassOf NCIT_C1244 @default.
- NCIT_C1244 subClassOf NCIT_C1590 @default.
- NCIT_C1244 subClassOf NCIT_C186664 @default.
- NCIT_C1244 subClassOf NCIT_C1908 @default.
- NCIT_C1244 subClassOf NCIT_C1909 @default.
- NCIT_C1244 subClassOf NCIT_C274 @default.
- NCIT_C1244 subClassOf NCIT_C2842 @default.
- NCIT_C1244 subClassOf NCIT_C902 @default.