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- NCIT_C124654 IAO_0000115 "An orally bioavailable, small molecule inhibitor of the acetate form of ralaniten, a N-terminal domain (NTD) of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration of ralaniten acetate, ralaniten specifically binds to the NTD of AR, thereby inhibiting both AR activation and the AR-mediated signaling pathway. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells." @default.
- NCIT_C124654 NCIT_A32 NCIT_C1909 @default.
- NCIT_C124654 NCIT_A7 NCIT_C17063 @default.
- NCIT_C124654 NCIT_NHC0 "C124654" @default.
- NCIT_C124654 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124654 NCIT_P107 "Ralaniten Acetate" @default.
- NCIT_C124654 NCIT_P108 "Ralaniten Acetate" @default.
- NCIT_C124654 NCIT_P208 "CL502886" @default.
- NCIT_C124654 NCIT_P210 "1637573-04-6" @default.
- NCIT_C124654 NCIT_P319 "L10K286T2H" @default.
- NCIT_C124654 NCIT_P322 "CTRP" @default.
- NCIT_C124654 NCIT_P322 "FDA" @default.
- NCIT_C124654 NCIT_P322 "GDC" @default.
- NCIT_C124654 NCIT_P329 "777367" @default.
- NCIT_C124654 NCIT_P330 "777367" @default.
- NCIT_C124654 NCIT_P375 "Ralaniten Acetate" @default.
- NCIT_C124654 NCIT_P399 "777367" @default.
- NCIT_C124654 NCIT_R124 NCIT_C17828 @default.
- NCIT_C124654 NCIT_R124 NCIT_C18992 @default.
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- NCIT_C124654 NCIT_R124 NCIT_C21124 @default.
- NCIT_C124654 NCIT_R124 NCIT_C40702 @default.
- NCIT_C124654 NCIT_R124 NCIT_C40703 @default.
- NCIT_C124654 NCIT_R125 NCIT_C17710 @default.
- NCIT_C124654 NCIT_R125 NCIT_C17828 @default.
- NCIT_C124654 NCIT_R125 NCIT_C18081 @default.
- NCIT_C124654 NCIT_R125 NCIT_C18966 @default.
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- NCIT_C124654 NCIT_R125 NCIT_C21050 @default.
- NCIT_C124654 NCIT_R125 NCIT_C28498 @default.
- NCIT_C124654 NCIT_R125 NCIT_C29857 @default.
- NCIT_C124654 NCIT_R125 NCIT_C29860 @default.
- NCIT_C124654 NCIT_R125 NCIT_C30022 @default.
- NCIT_C124654 NCIT_R146 NCIT_C128290 @default.
- NCIT_C124654 NCIT_R146 NCIT_C17021 @default.
- NCIT_C124654 NCIT_R146 NCIT_C17063 @default.
- NCIT_C124654 NCIT_R146 NCIT_C17207 @default.
- NCIT_C124654 NCIT_R146 NCIT_C17671 @default.
- NCIT_C124654 NCIT_R146 NCIT_C17728 @default.
- NCIT_C124654 NCIT_R146 NCIT_C18106 @default.
- NCIT_C124654 NCIT_R146 NCIT_C18108 @default.
- NCIT_C124654 NCIT_R146 NCIT_C18466 @default.
- NCIT_C124654 NCIT_R146 NCIT_C20027 @default.
- NCIT_C124654 NCIT_R146 NCIT_C26199 @default.
- NCIT_C124654 NCIT_R146 NCIT_C26548 @default.
- NCIT_C124654 normalizedInformationContent "100" @default.
- NCIT_C124654 referenceCount "1" @default.
- NCIT_C124654 hasExactSynonym "1,2-Propanediol, 3-(4-(1-(4-((2S)-2-(acetyloxy)-3-chloropropoxy)phenyl)-1-methylethyl)phenoxy)-, 1,2-Diacetate, (2S)-" @default.
- NCIT_C124654 hasExactSynonym "AR Inhibitor EPI-506" @default.
- NCIT_C124654 hasExactSynonym "EPI-506" @default.
- NCIT_C124654 hasExactSynonym "RALANITEN ACETATE" @default.
- NCIT_C124654 hasExactSynonym "Ralaniten Acetate" @default.
- NCIT_C124654 inSubset NCIT_C116977 @default.
- NCIT_C124654 inSubset NCIT_C116978 @default.
- NCIT_C124654 inSubset NCIT_C128784 @default.
- NCIT_C124654 inSubset NCIT_C157711 @default.
- NCIT_C124654 inSubset NCIT_C157712 @default.
- NCIT_C124654 inSubset NCIT_C176424 @default.
- NCIT_C124654 inSubset NCIT_C177537 @default.
- NCIT_C124654 inSubset NCIT_C63923 @default.
- NCIT_C124654 type Class @default.
- NCIT_C124654 isDefinedBy ncit.owl @default.
- NCIT_C124654 label "Ralaniten Acetate" @default.
- NCIT_C124654 subClassOf B2223a6a61065674e33a431ee76b3a3c4 @default.
- NCIT_C124654 subClassOf B6fadd9583040746c080508089d99c7be @default.
- NCIT_C124654 subClassOf B8431d7da0c8a6e29934412b752a9f67b @default.
- NCIT_C124654 subClassOf B8945453b73c5318e1a426083e30512cb @default.
- NCIT_C124654 subClassOf Baaf2ec88edb36e1d8b84e04356f9ad97 @default.
- NCIT_C124654 subClassOf Bced6705e9caa1920abee0bf34383c6d5 @default.
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- NCIT_C124654 subClassOf NCIT_C124654 @default.
- NCIT_C124654 subClassOf NCIT_C146993 @default.
- NCIT_C124654 subClassOf NCIT_C147908 @default.
- NCIT_C124654 subClassOf NCIT_C163758 @default.
- NCIT_C124654 subClassOf NCIT_C1908 @default.
- NCIT_C124654 subClassOf NCIT_C1909 @default.
- NCIT_C124654 subClassOf NCIT_C242 @default.
- NCIT_C124654 subClassOf NCIT_C274 @default.
- NCIT_C124654 subClassOf NCIT_C547 @default.