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- NCIT_C124655 IAO_0000115 "Human autologous lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous T-lymphocytes expressing NY-ESO-1-C259-specific enhanced T-cell receptors bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for SLLMWITQC, an NY-ESO-1-derived peptide, in a complex with human leukocyte antigen (HLA) A2 peptide." @default.
- NCIT_C124655 NCIT_NHC0 "C124655" @default.
- NCIT_C124655 NCIT_P106 "Cell" @default.
- NCIT_C124655 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124655 NCIT_P108 "Autologous T-lymphocytes-expressing NY-ESO-1-C259-specific Enhanced T-cell Receptors" @default.
- NCIT_C124655 NCIT_P208 "CL502887" @default.
- NCIT_C124655 NCIT_P329 "776841" @default.
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- NCIT_C124655 hasExactSynonym "Autologous T-lymphocytes-expressing NY-ESO-1-C259-specific Enhanced T-cell Receptors" @default.
- NCIT_C124655 hasExactSynonym "NY-ESO-1/C259T" @default.
- NCIT_C124655 hasExactSynonym "NY-ESO-1C259T" @default.
- NCIT_C124655 hasExactSynonym "NY-ESOc259T" @default.
- NCIT_C124655 inSubset NCIT_C128784 @default.
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- NCIT_C124655 type Class @default.
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- NCIT_C124655 label "Autologous T-lymphocytes-expressing NY-ESO-1-C259-specific Enhanced T-cell Receptors" @default.
- NCIT_C124655 subClassOf NCIT_C124655 @default.
- NCIT_C124655 subClassOf NCIT_C129820 @default.
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- NCIT_C124655 subClassOf NCIT_C307 @default.
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