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- NCIT_C124657 IAO_0000115 "A longer-acting antibody directed against terminal complement protein C5, with potential anti-inflammatory activity. Upon administration, ravulizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and preventing the complement-mediated destruction of red blood cells (RBCs) as seen in paroxysmal nocturnal hemoglobinuria (PNH). Compared to other anti-C5 antibodies, ALXN1210 is longer-acting and allows for monthly dosing. C5, a complement pathway protein, is expressed at high levels by the liver." @default.
- NCIT_C124657 NCIT_A7 NCIT_C21539 @default.
- NCIT_C124657 NCIT_NHC0 "C124657" @default.
- NCIT_C124657 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124657 NCIT_P107 "Ravulizumab" @default.
- NCIT_C124657 NCIT_P108 "Ravulizumab" @default.
- NCIT_C124657 NCIT_P208 "CL502889" @default.
- NCIT_C124657 NCIT_P210 "1803171-55-2" @default.
- NCIT_C124657 NCIT_P302 "paroxysmal nocturnal hemoglobinuria (PNH)" @default.
- NCIT_C124657 NCIT_P319 "C3VX249T6L" @default.
- NCIT_C124657 NCIT_P322 "CTRP" @default.
- NCIT_C124657 NCIT_P322 "FDA" @default.
- NCIT_C124657 NCIT_P329 "776919" @default.
- NCIT_C124657 NCIT_P330 "776919" @default.
- NCIT_C124657 NCIT_P399 "776919" @default.
- NCIT_C124657 NCIT_R124 NCIT_C17710 @default.
- NCIT_C124657 NCIT_R124 NCIT_C17828 @default.
- NCIT_C124657 NCIT_R124 NCIT_C18219 @default.
- NCIT_C124657 NCIT_R124 NCIT_C19986 @default.
- NCIT_C124657 NCIT_R124 NCIT_C40474 @default.
- NCIT_C124657 normalizedInformationContent "100" @default.
- NCIT_C124657 referenceCount "1" @default.
- NCIT_C124657 hasExactSynonym "ALXN 1210" @default.
- NCIT_C124657 hasExactSynonym "ALXN1210" @default.
- NCIT_C124657 hasExactSynonym "RAVULIZUMAB" @default.
- NCIT_C124657 hasExactSynonym "Ravulizumab" @default.
- NCIT_C124657 hasExactSynonym "Ravulizumab-cwvz" @default.
- NCIT_C124657 hasExactSynonym "Ultomiris" @default.
- NCIT_C124657 inSubset NCIT_C116977 @default.
- NCIT_C124657 inSubset NCIT_C116978 @default.
- NCIT_C124657 inSubset NCIT_C173381 @default.
- NCIT_C124657 inSubset NCIT_C173383 @default.
- NCIT_C124657 inSubset NCIT_C176424 @default.
- NCIT_C124657 inSubset NCIT_C63923 @default.
- NCIT_C124657 type Class @default.
- NCIT_C124657 isDefinedBy ncit.owl @default.
- NCIT_C124657 label "Ravulizumab" @default.
- NCIT_C124657 subClassOf NCIT_C124657 @default.
- NCIT_C124657 subClassOf NCIT_C1908 @default.
- NCIT_C124657 subClassOf NCIT_C1909 @default.
- NCIT_C124657 subClassOf NCIT_C199456 @default.
- NCIT_C124657 subClassOf NCIT_C20401 @default.
- NCIT_C124657 subClassOf NCIT_C307 @default.
- NCIT_C124657 subClassOf NCIT_C308 @default.
- NCIT_C124657 subClassOf NCIT_C78275 @default.