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- NCIT_C124660 IAO_0000115 "A topical spray formulation containing the prostone cobiprostone, a type 2 chloride channel (ClC-2) agonist, with potential mucosal protective and anti-mucositis activities. Upon administration of cobiprostine via a spray into the oral cavity, cobiprostone specifically binds to and activates the ClC2 channel located on the mucosal membrane. This activates the epithelial ClC2 channel, enhances secretion of chloride, and promotes epithelial barrier repair. This prevents or reduces mucosal injury and reduces mucositis. ClC2 plays a key role in the protection of mucosal barrier function." @default.
- NCIT_C124660 NCIT_NHC0 "C124660" @default.
- NCIT_C124660 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124660 NCIT_P108 "Cobiprostone Spray" @default.
- NCIT_C124660 NCIT_P207 "C4086205" @default.
- NCIT_C124660 NCIT_P329 "776924" @default.
- NCIT_C124660 NCIT_P330 "776924" @default.
- NCIT_C124660 NCIT_P399 "776924" @default.
- NCIT_C124660 normalizedInformationContent "100" @default.
- NCIT_C124660 referenceCount "1" @default.
- NCIT_C124660 hasExactSynonym "Cobiprostone Oral Spray" @default.
- NCIT_C124660 hasExactSynonym "Cobiprostone Spray" @default.
- NCIT_C124660 hasExactSynonym "SPI-8811" @default.
- NCIT_C124660 inSubset NCIT_C176424 @default.
- NCIT_C124660 type Class @default.
- NCIT_C124660 isDefinedBy ncit.owl @default.
- NCIT_C124660 label "Cobiprostone Spray" @default.
- NCIT_C124660 subClassOf NCIT_C124660 @default.
- NCIT_C124660 subClassOf NCIT_C1908 @default.
- NCIT_C124660 subClassOf NCIT_C1909 @default.
- NCIT_C124660 subClassOf NCIT_C2080 @default.
- NCIT_C124660 subClassOf NCIT_C2459 @default.
- NCIT_C124660 subClassOf NCIT_C26170 @default.