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- NCIT_C124843 IAO_0000115 "A proprietary, live-attenuated, double-deleted (LADD) strain of the Gram-positive bacterium Listeria monocytogenes (Lm) encoding the tumor-associated antigens (TAAs) epidermal growth factor receptor mutant form EGFRvIII and human mesothelin, with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, the live-attenuated Listeria monocytogenes encoding EGFRvIII-mesothelin vaccine Pemlimogene merolisbac is taken up by antigen-presenting cells (APCs), including dendritic cells (DCs). EGFRvIII and mesothelin are subsequently expressed by the APCs and then processed and presented to the immune system by both major histocompatibility complex (MHC) class I and II molecules. This activates the immune system and leads to the recruitment and activation of cytotoxic T-lymphocytes (CTLs) against EGFRvIII- and mesothelin-expressing tumor cells, eventually resulting in tumor cell lysis. EGFRvIII and mesothelin are overexpressed in many types of cancer. Two genes contributing to the virulence of Lm have been removed to minimize the risk of infection." @default.
- NCIT_C124843 NCIT_A32 NCIT_C1909 @default.
- NCIT_C124843 NCIT_A7 NCIT_C101140 @default.
- NCIT_C124843 NCIT_A7 NCIT_C20887 @default.
- NCIT_C124843 NCIT_NHC0 "C124843" @default.
- NCIT_C124843 NCIT_P106 "Bacterium" @default.
- NCIT_C124843 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124843 NCIT_P107 "Pemlimogene Merolisbac" @default.
- NCIT_C124843 NCIT_P108 "Pemlimogene Merolisbac" @default.
- NCIT_C124843 NCIT_P208 "CL503062" @default.
- NCIT_C124843 NCIT_P319 "S2EGO8116S" @default.
- NCIT_C124843 NCIT_P322 "CTRP" @default.
- NCIT_C124843 NCIT_P322 "FDA" @default.
- NCIT_C124843 NCIT_P322 "GDC" @default.
- NCIT_C124843 NCIT_P329 "778079" @default.
- NCIT_C124843 NCIT_P330 "778079" @default.
- NCIT_C124843 NCIT_P375 "Pemlimogene Merolisbac" @default.
- NCIT_C124843 NCIT_P399 "778079" @default.
- NCIT_C124843 normalizedInformationContent "100" @default.
- NCIT_C124843 referenceCount "1" @default.
- NCIT_C124843 hasExactSynonym "ADU-214" @default.
- NCIT_C124843 hasExactSynonym "JNJ-64041757" @default.
- NCIT_C124843 hasExactSynonym "LADD Listeria monocytogenes JNJ-64041757" @default.
- NCIT_C124843 hasExactSynonym "PEMLIMOGENE MEROLISBAC" @default.
- NCIT_C124843 hasExactSynonym "Pemlimogene Merolisbac" @default.
- NCIT_C124843 inSubset NCIT_C116977 @default.
- NCIT_C124843 inSubset NCIT_C116978 @default.
- NCIT_C124843 inSubset NCIT_C128784 @default.
- NCIT_C124843 inSubset NCIT_C157711 @default.
- NCIT_C124843 inSubset NCIT_C157712 @default.
- NCIT_C124843 inSubset NCIT_C176424 @default.
- NCIT_C124843 inSubset NCIT_C177537 @default.
- NCIT_C124843 inSubset NCIT_C63923 @default.
- NCIT_C124843 type Class @default.
- NCIT_C124843 isDefinedBy ncit.owl @default.
- NCIT_C124843 label "Pemlimogene Merolisbac" @default.
- NCIT_C124843 subClassOf NCIT_C124843 @default.
- NCIT_C124843 subClassOf NCIT_C129820 @default.
- NCIT_C124843 subClassOf NCIT_C1663 @default.
- NCIT_C124843 subClassOf NCIT_C1908 @default.
- NCIT_C124843 subClassOf NCIT_C1909 @default.
- NCIT_C124843 subClassOf NCIT_C274 @default.
- NCIT_C124843 subClassOf NCIT_C307 @default.
- NCIT_C124843 subClassOf NCIT_C308 @default.
- NCIT_C124843 subClassOf NCIT_C62761 @default.
- NCIT_C124843 subClassOf NCIT_C923 @default.
- NCIT_C124843 subClassOf NCIT_C96390 @default.
- NCIT_C124843 subClassOf NCIT_C97116 @default.