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- NCIT_C124929 IAO_0000115 "A radioconjugate consisting of the somatostatin antagonistic peptide satoreotide tetraxetan (JR11) that is linked, via the chelating agent dodecanetetraacetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and imaging activity during positron emission tomography/computed tomography (PET/CT). Upon administration, lutetium Lu 177-DOTA-JR11 binds to somatostatin receptors (SSTRs), with high affinity for SSTR2, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most normal tissues express low levels of SSTRs." @default.
- NCIT_C124929 NCIT_A32 NCIT_C1909 @default.
- NCIT_C124929 NCIT_A7 NCIT_C17333 @default.
- NCIT_C124929 NCIT_A7 NCIT_C17922 @default.
- NCIT_C124929 NCIT_NHC0 "C124929" @default.
- NCIT_C124929 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124929 NCIT_P107 "Lutetium Lu 177 DOTA-JR11" @default.
- NCIT_C124929 NCIT_P108 "Lutetium Lu 177 Satoreotide Tetraxetan" @default.
- NCIT_C124929 NCIT_P171 "24963127" @default.
- NCIT_C124929 NCIT_P208 "CL503798" @default.
- NCIT_C124929 NCIT_P210 "1934243-21-6" @default.
- NCIT_C124929 NCIT_P319 "CAX3X53UL6" @default.
- NCIT_C124929 NCIT_P322 "CTRP" @default.
- NCIT_C124929 NCIT_P322 "FDA" @default.
- NCIT_C124929 NCIT_P322 "GDC" @default.
- NCIT_C124929 NCIT_P329 "777267" @default.
- NCIT_C124929 NCIT_P330 "777267" @default.
- NCIT_C124929 NCIT_P375 "Lutetium Lu 177 Satoreotide Tetraxetan" @default.
- NCIT_C124929 NCIT_P399 "777267" @default.
- NCIT_C124929 normalizedInformationContent "100" @default.
- NCIT_C124929 referenceCount "1" @default.
- NCIT_C124929 hasExactSynonym "177Lu-DOTA-Cpa-c[d-Cys-Aph(Hor)-d-Aph(Cbm)-Lys-Thr-Cys]-d-Tyr-NH2" @default.
- NCIT_C124929 hasExactSynonym "177Lu-DOTA-JR11" @default.
- NCIT_C124929 hasExactSynonym "177Lu-DOTA-[Cpa-c(DCys-Aph(Hor)-DAph(Cbm)-Lys-Thr-Cys)-DTyr-NH2]" @default.
- NCIT_C124929 hasExactSynonym "Lu-177 OPS-201" @default.
- NCIT_C124929 hasExactSynonym "Lutetium Lu 177 Satoreotide Tetraxetan" @default.
- NCIT_C124929 hasExactSynonym "SATOREOTIDE TETRAXETAN LUTETIUM-177" @default.
- NCIT_C124929 hasExactSynonym "SOMther" @default.
- NCIT_C124929 hasExactSynonym "Satoreotide Tetraxetan Lutetium-177" @default.
- NCIT_C124929 inSubset NCIT_C116977 @default.
- NCIT_C124929 inSubset NCIT_C116978 @default.
- NCIT_C124929 inSubset NCIT_C128784 @default.
- NCIT_C124929 inSubset NCIT_C157711 @default.
- NCIT_C124929 inSubset NCIT_C157712 @default.
- NCIT_C124929 inSubset NCIT_C176424 @default.
- NCIT_C124929 inSubset NCIT_C177537 @default.
- NCIT_C124929 inSubset NCIT_C63923 @default.
- NCIT_C124929 type Class @default.
- NCIT_C124929 isDefinedBy ncit.owl @default.
- NCIT_C124929 label "Lutetium Lu 177 Satoreotide Tetraxetan" @default.
- NCIT_C124929 subClassOf NCIT_C124929 @default.
- NCIT_C124929 subClassOf NCIT_C129819 @default.
- NCIT_C124929 subClassOf NCIT_C1446 @default.
- NCIT_C124929 subClassOf NCIT_C1908 @default.
- NCIT_C124929 subClassOf NCIT_C1909 @default.
- NCIT_C124929 subClassOf NCIT_C2124 @default.
- NCIT_C124929 subClassOf NCIT_C274 @default.