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- NCIT_C124930 IAO_0000115 "A radioconjugate consisting of the somatostatin antagonistic peptide satoreotide that is linked via the chelating agent tetraxetan (dodecanetetraacetic acid; DOTA), to the beta-emitting radioisotope gallium Ga 68, with potential imaging activity during positron emission topography/computed tomography (PET/CT). Upon administration, gallium Ga 68 satoreotide tetraxetan binds to somatostatin receptors (SSTRs), with high affinity for SSTR2, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate can be used to quantify tumor uptake of satoreotide using PET/CT. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most normal tissues express low levels of SSTRs." @default.
- NCIT_C124930 NCIT_A7 NCIT_C17333 @default.
- NCIT_C124930 NCIT_A7 NCIT_C17922 @default.
- NCIT_C124930 NCIT_NHC0 "C124930" @default.
- NCIT_C124930 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124930 NCIT_P107 "Gallium Ga 68 Satoreotide Tetraxetan" @default.
- NCIT_C124930 NCIT_P108 "Gallium Ga 68 Satoreotide Tetraxetan" @default.
- NCIT_C124930 NCIT_P171 "22851637" @default.
- NCIT_C124930 NCIT_P208 "CL503799" @default.
- NCIT_C124930 NCIT_P210 "1934243-18-1" @default.
- NCIT_C124930 NCIT_P322 "CTRP" @default.
- NCIT_C124930 NCIT_P329 "777268" @default.
- NCIT_C124930 NCIT_P330 "777268" @default.
- NCIT_C124930 NCIT_P399 "777268" @default.
- NCIT_C124930 normalizedInformationContent "100" @default.
- NCIT_C124930 referenceCount "1" @default.
- NCIT_C124930 hasExactSynonym "68Ga-DOTA-Cpa-c[d-Cys-Aph(Hor)-d-Aph(Cbm)-Lys-Thr-Cys]-d-Tyr-NH2" @default.
- NCIT_C124930 hasExactSynonym "68Ga-DOTA-JR11" @default.
- NCIT_C124930 hasExactSynonym "68Ga-DOTA-[Cpa-c(DCys-Aph(Hor)-DAph(Cbm)-Lys-Thr-Cys)-DTyr-NH2]" @default.
- NCIT_C124930 hasExactSynonym "Gallium Ga 68 DOTA-JR11" @default.
- NCIT_C124930 hasExactSynonym "Gallium Ga 68 Satoreotide Tetraxetan" @default.
- NCIT_C124930 inSubset NCIT_C116977 @default.
- NCIT_C124930 inSubset NCIT_C116978 @default.
- NCIT_C124930 inSubset NCIT_C176424 @default.
- NCIT_C124930 type Class @default.
- NCIT_C124930 isDefinedBy ncit.owl @default.
- NCIT_C124930 label "Gallium Ga 68 Satoreotide Tetraxetan" @default.
- NCIT_C124930 subClassOf NCIT_C124930 @default.
- NCIT_C124930 subClassOf NCIT_C1446 @default.
- NCIT_C124930 subClassOf NCIT_C1908 @default.
- NCIT_C124930 subClassOf NCIT_C1909 @default.
- NCIT_C124930 subClassOf NCIT_C2124 @default.