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- NCIT_C124993 IAO_0000115 "A human bispecific antibody targeting both epidermal growth factor receptor EGFR and hepatocyte growth factor receptor (HGFR; cMet), with potential antineoplastic activity. Upon administration, amivantamab simultaneously targets and binds to wild-type or certain mutant forms of both EGFR and cMet expressed on cancer cells, thereby preventing receptor phosphorylation. This prevents the activation of both EGFR- and cMet-mediated signaling pathways. In addition, binding results in receptor degradation, which further inhibits EGFR- and cMet-mediated signaling. JNJ-61186372 also causes antibody-dependent cellular cytotoxicity (ADCC). Altogether, this results in the inhibition of tumor cell proliferation. EGFR and cMet, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation." @default.
- NCIT_C124993 NCIT_A32 NCIT_C1909 @default.
- NCIT_C124993 NCIT_A7 NCIT_C17068 @default.
- NCIT_C124993 NCIT_A7 NCIT_C18186 @default.
- NCIT_C124993 NCIT_NHC0 "C124993" @default.
- NCIT_C124993 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C124993 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C124993 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124993 NCIT_P107 "Amivantamab" @default.
- NCIT_C124993 NCIT_P108 "Amivantamab" @default.
- NCIT_C124993 NCIT_P208 "CL503840" @default.
- NCIT_C124993 NCIT_P210 "2171511-58-1" @default.
- NCIT_C124993 NCIT_P302 "adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations" @default.
- NCIT_C124993 NCIT_P319 "0JSR7Z0NB6" @default.
- NCIT_C124993 NCIT_P322 "CTRP" @default.
- NCIT_C124993 NCIT_P322 "FDA" @default.
- NCIT_C124993 NCIT_P322 "GDC" @default.
- NCIT_C124993 NCIT_P329 "777269" @default.
- NCIT_C124993 NCIT_P330 "777269" @default.
- NCIT_C124993 NCIT_P375 "Amivantamab" @default.
- NCIT_C124993 NCIT_P375 "Anti-EGFR/c-Met Bispecific Antibody JNJ-61186372" @default.
- NCIT_C124993 NCIT_P399 "777269" @default.
- NCIT_C124993 NCIT_R124 NCIT_C17710 @default.
- NCIT_C124993 NCIT_R124 NCIT_C17828 @default.
- NCIT_C124993 NCIT_R124 NCIT_C18219 @default.
- NCIT_C124993 NCIT_R124 NCIT_C19986 @default.
- NCIT_C124993 NCIT_R124 NCIT_C40474 @default.
- NCIT_C124993 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C124993 referenceCount "2" @default.
- NCIT_C124993 hasExactSynonym "AMIVANTAMAB" @default.
- NCIT_C124993 hasExactSynonym "Amivantamab" @default.
- NCIT_C124993 hasExactSynonym "Amivantamab-vmjw" @default.
- NCIT_C124993 hasExactSynonym "Anti-EGFR/c-Met Bispecific Antibody JNJ-61186372" @default.
- NCIT_C124993 hasExactSynonym "CNTO-4424" @default.
- NCIT_C124993 hasExactSynonym "JNJ-611" @default.
- NCIT_C124993 hasExactSynonym "JNJ-61186372" @default.
- NCIT_C124993 hasExactSynonym "JNJ61186372" @default.
- NCIT_C124993 hasExactSynonym "Rybrevant" @default.
- NCIT_C124993 inSubset NCIT_C116977 @default.
- NCIT_C124993 inSubset NCIT_C116978 @default.
- NCIT_C124993 inSubset NCIT_C128784 @default.
- NCIT_C124993 inSubset NCIT_C157711 @default.
- NCIT_C124993 inSubset NCIT_C157712 @default.
- NCIT_C124993 inSubset NCIT_C176424 @default.
- NCIT_C124993 inSubset NCIT_C177537 @default.
- NCIT_C124993 inSubset NCIT_C63923 @default.
- NCIT_C124993 type Class @default.
- NCIT_C124993 isDefinedBy ncit.owl @default.
- NCIT_C124993 label "Amivantamab" @default.
- NCIT_C124993 subClassOf NCIT_C124993 @default.
- NCIT_C124993 subClassOf NCIT_C129821 @default.
- NCIT_C124993 subClassOf NCIT_C129822 @default.
- NCIT_C124993 subClassOf NCIT_C133878 @default.
- NCIT_C124993 subClassOf NCIT_C1454 @default.
- NCIT_C124993 subClassOf NCIT_C163758 @default.
- NCIT_C124993 subClassOf NCIT_C163952 @default.
- NCIT_C124993 subClassOf NCIT_C164000 @default.
- NCIT_C124993 subClassOf NCIT_C164001 @default.
- NCIT_C124993 subClassOf NCIT_C1908 @default.
- NCIT_C124993 subClassOf NCIT_C1909 @default.
- NCIT_C124993 subClassOf NCIT_C20401 @default.
- NCIT_C124993 subClassOf NCIT_C274 @default.
- NCIT_C124993 subClassOf NCIT_C28227 @default.
- NCIT_C124993 subClassOf NCIT_C307 @default.
- NCIT_C124993 subClassOf NCIT_C308 @default.