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- NCIT_C124998 IAO_0000115 "A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to the tumor-associated antigen (TAA) mucin-1 (MUC1), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient with MUC1-positive tumors and are exposed ex vivo to dendritic cells (DCs) that are pulsed with a MUC1 peptide to generate MUC1-specific CTLs, which are subsequently expanded in vitro. Upon re-infusion of autologous CTLs induced with MUC1 peptide-pulsed DCs to the patient, the CTLs target and lyse the MUC1-expressing tumor cells. This inhibits tumor cell proliferation. MUC1 is expressed by a variety of tumor cell types." @default.
- NCIT_C124998 NCIT_NHC0 "C124998" @default.
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- NCIT_C124998 NCIT_P108 "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Peptide-pulsed Dendritic Cells" @default.
- NCIT_C124998 NCIT_P208 "CL503844" @default.
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- NCIT_C124998 hasExactSynonym "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Peptide-pulsed Dendritic Cells" @default.
- NCIT_C124998 hasExactSynonym "MUC1-Peptide-DC-CTL" @default.
- NCIT_C124998 inSubset NCIT_C128784 @default.
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- NCIT_C124998 type Class @default.
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- NCIT_C124998 label "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Peptide-pulsed Dendritic Cells" @default.
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