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- NCIT_C124999 IAO_0000115 "A humanized monoclonal antibody against the immune receptor human killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 (KIR3DL2), with potential immunomodulating and antineoplastic activities. Upon administration, lacutamab binds to KIR3DL2 expressed on certain tumor cells. This recruits natural killer (NK) cells and leads to lysis of KIR3DL2-expressing tumor cells. In addition, IPH4102 induces antibody-dependent cellular cytotoxicity (ADCC), thereby further eliminating tumor cells. KIR3DL2, a tumor-associated antigen (TAA) and inhibitory receptor of the KIR family, is specifically expressed in most subtypes of cutaneous T-cell lymphomas (CTCL) and expressed only on a fraction of normal NK cells." @default.
- NCIT_C124999 NCIT_A32 NCIT_C1909 @default.
- NCIT_C124999 NCIT_A7 NCIT_C171047 @default.
- NCIT_C124999 NCIT_NHC0 "C124999" @default.
- NCIT_C124999 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C124999 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C124999 NCIT_P107 "Lacutamab" @default.
- NCIT_C124999 NCIT_P108 "Lacutamab" @default.
- NCIT_C124999 NCIT_P208 "CL503845" @default.
- NCIT_C124999 NCIT_P210 "2187368-16-5" @default.
- NCIT_C124999 NCIT_P319 "N8O7MY0VNS" @default.
- NCIT_C124999 NCIT_P322 "CTRP" @default.
- NCIT_C124999 NCIT_P322 "FDA" @default.
- NCIT_C124999 NCIT_P322 "GDC" @default.
- NCIT_C124999 NCIT_P329 "777272" @default.
- NCIT_C124999 NCIT_P330 "777272" @default.
- NCIT_C124999 NCIT_P375 "Lacutamab" @default.
- NCIT_C124999 NCIT_P399 "777272" @default.
- NCIT_C124999 NCIT_R124 NCIT_C17710 @default.
- NCIT_C124999 NCIT_R124 NCIT_C17828 @default.
- NCIT_C124999 NCIT_R124 NCIT_C18219 @default.
- NCIT_C124999 NCIT_R124 NCIT_C19986 @default.
- NCIT_C124999 NCIT_R124 NCIT_C40474 @default.
- NCIT_C124999 normalizedInformationContent "100" @default.
- NCIT_C124999 referenceCount "1" @default.
- NCIT_C124999 hasExactSynonym "Anti-KIR3DL2 Monoclonal Antibody IPH4102" @default.
- NCIT_C124999 hasExactSynonym "Anti-KIR3DL2 mAb IPH4102" @default.
- NCIT_C124999 hasExactSynonym "IPH-4102" @default.
- NCIT_C124999 hasExactSynonym "IPH4102" @default.
- NCIT_C124999 hasExactSynonym "LACUTAMAB" @default.
- NCIT_C124999 hasExactSynonym "Lacutamab" @default.
- NCIT_C124999 inSubset NCIT_C116977 @default.
- NCIT_C124999 inSubset NCIT_C116978 @default.
- NCIT_C124999 inSubset NCIT_C128784 @default.
- NCIT_C124999 inSubset NCIT_C157711 @default.
- NCIT_C124999 inSubset NCIT_C157712 @default.
- NCIT_C124999 inSubset NCIT_C176424 @default.
- NCIT_C124999 inSubset NCIT_C177537 @default.
- NCIT_C124999 inSubset NCIT_C63923 @default.
- NCIT_C124999 type Class @default.
- NCIT_C124999 isDefinedBy ncit.owl @default.
- NCIT_C124999 label "Lacutamab" @default.
- NCIT_C124999 subClassOf NCIT_C124999 @default.
- NCIT_C124999 subClassOf NCIT_C129821 @default.
- NCIT_C124999 subClassOf NCIT_C129822 @default.
- NCIT_C124999 subClassOf NCIT_C1908 @default.
- NCIT_C124999 subClassOf NCIT_C1909 @default.
- NCIT_C124999 subClassOf NCIT_C20401 @default.
- NCIT_C124999 subClassOf NCIT_C274 @default.
- NCIT_C124999 subClassOf NCIT_C307 @default.
- NCIT_C124999 subClassOf NCIT_C308 @default.