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- NCIT_C125003 IAO_0000115 "An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, naporafenib binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival." @default.
- NCIT_C125003 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125003 NCIT_NHC0 "C125003" @default.
- NCIT_C125003 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125003 NCIT_P107 "pan-RAF Inhibitor LXH254" @default.
- NCIT_C125003 NCIT_P108 "Naporafenib" @default.
- NCIT_C125003 NCIT_P208 "CL503849" @default.
- NCIT_C125003 NCIT_P210 "1800398-38-2" @default.
- NCIT_C125003 NCIT_P319 "15JL80DG6H" @default.
- NCIT_C125003 NCIT_P322 "CTRP" @default.
- NCIT_C125003 NCIT_P322 "FDA" @default.
- NCIT_C125003 NCIT_P322 "GDC" @default.
- NCIT_C125003 NCIT_P329 "778192" @default.
- NCIT_C125003 NCIT_P330 "778192" @default.
- NCIT_C125003 NCIT_P375 "pan-RAF Inhibitor LXH254" @default.
- NCIT_C125003 NCIT_P399 "778192" @default.
- NCIT_C125003 normalizedInformationContent "100" @default.
- NCIT_C125003 referenceCount "1" @default.
- NCIT_C125003 hasExactSynonym "LXH 254" @default.
- NCIT_C125003 hasExactSynonym "LXH-254" @default.
- NCIT_C125003 hasExactSynonym "LXH254" @default.
- NCIT_C125003 hasExactSynonym "NAPORAFENIB" @default.
- NCIT_C125003 hasExactSynonym "Naporafenib" @default.
- NCIT_C125003 hasExactSynonym "Raf Family Kinase Inhibitor LXH254" @default.
- NCIT_C125003 hasExactSynonym "pan-RAF Inhibitor LXH254" @default.
- NCIT_C125003 hasExactSynonym "pan-RAF Kinase Inhibitor LXH254" @default.
- NCIT_C125003 inSubset NCIT_C116977 @default.
- NCIT_C125003 inSubset NCIT_C116978 @default.
- NCIT_C125003 inSubset NCIT_C128784 @default.
- NCIT_C125003 inSubset NCIT_C157711 @default.
- NCIT_C125003 inSubset NCIT_C157712 @default.
- NCIT_C125003 inSubset NCIT_C176424 @default.
- NCIT_C125003 inSubset NCIT_C177537 @default.
- NCIT_C125003 inSubset NCIT_C63923 @default.
- NCIT_C125003 type Class @default.
- NCIT_C125003 isDefinedBy ncit.owl @default.
- NCIT_C125003 label "Naporafenib" @default.
- NCIT_C125003 subClassOf NCIT_C125003 @default.
- NCIT_C125003 subClassOf NCIT_C129824 @default.
- NCIT_C125003 subClassOf NCIT_C129825 @default.
- NCIT_C125003 subClassOf NCIT_C1404 @default.
- NCIT_C125003 subClassOf NCIT_C163758 @default.
- NCIT_C125003 subClassOf NCIT_C1908 @default.
- NCIT_C125003 subClassOf NCIT_C1909 @default.
- NCIT_C125003 subClassOf NCIT_C2189 @default.
- NCIT_C125003 subClassOf NCIT_C2336 @default.
- NCIT_C125003 subClassOf NCIT_C274 @default.
- NCIT_C125003 subClassOf NCIT_C471 @default.
- NCIT_C125003 subClassOf NCIT_C61074 @default.