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- NCIT_C125080 IAO_0000115 "The sodium salt form of tilsotolimod, a proprietary synthetic oligonucleotide-based agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon administration, tilsotolimod binds to and activates TLR9 expressed by plasmacytoid dendritic cells (pDCs) and B-cells. This initiates immune signaling pathways, activates B-cells and pDCs, and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity." @default.
- NCIT_C125080 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125080 NCIT_A6 NCIT_C152632 @default.
- NCIT_C125080 NCIT_A7 NCIT_C96048 @default.
- NCIT_C125080 NCIT_NHC0 "C125080" @default.
- NCIT_C125080 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125080 NCIT_P107 "Tilsotolimod Sodium" @default.
- NCIT_C125080 NCIT_P108 "Tilsotolimod Sodium" @default.
- NCIT_C125080 NCIT_P208 "CL503920" @default.
- NCIT_C125080 NCIT_P210 "2089768-67-0" @default.
- NCIT_C125080 NCIT_P319 "I6CNU8SY0F" @default.
- NCIT_C125080 NCIT_P322 "CTRP" @default.
- NCIT_C125080 NCIT_P322 "FDA" @default.
- NCIT_C125080 NCIT_P322 "GDC" @default.
- NCIT_C125080 NCIT_P329 "777995" @default.
- NCIT_C125080 NCIT_P330 "777995" @default.
- NCIT_C125080 NCIT_P375 "Tilsotolimod Sodium" @default.
- NCIT_C125080 NCIT_P399 "777995" @default.
- NCIT_C125080 normalizedInformationContent "100" @default.
- NCIT_C125080 referenceCount "1" @default.
- NCIT_C125080 hasExactSynonym "IMO 2125" @default.
- NCIT_C125080 hasExactSynonym "IMO-2125" @default.
- NCIT_C125080 hasExactSynonym "TILSOTOLIMOD SODIUM" @default.
- NCIT_C125080 hasExactSynonym "TLR9 Agonist IMO-2125" @default.
- NCIT_C125080 hasExactSynonym "Tilsotolimod Sodium" @default.
- NCIT_C125080 inSubset NCIT_C116977 @default.
- NCIT_C125080 inSubset NCIT_C116978 @default.
- NCIT_C125080 inSubset NCIT_C128784 @default.
- NCIT_C125080 inSubset NCIT_C157711 @default.
- NCIT_C125080 inSubset NCIT_C157712 @default.
- NCIT_C125080 inSubset NCIT_C176424 @default.
- NCIT_C125080 inSubset NCIT_C177537 @default.
- NCIT_C125080 inSubset NCIT_C63923 @default.
- NCIT_C125080 type Class @default.
- NCIT_C125080 isDefinedBy ncit.owl @default.
- NCIT_C125080 label "Tilsotolimod Sodium" @default.
- NCIT_C125080 subClassOf NCIT_C125080 @default.
- NCIT_C125080 subClassOf NCIT_C177174 @default.
- NCIT_C125080 subClassOf NCIT_C177175 @default.
- NCIT_C125080 subClassOf NCIT_C1908 @default.
- NCIT_C125080 subClassOf NCIT_C1909 @default.
- NCIT_C125080 subClassOf NCIT_C2139 @default.
- NCIT_C125080 subClassOf NCIT_C308 @default.