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- NCIT_C125185 IAO_0000115 "Autologous activated T-cells that have been coated with bispecific antibodies (BiAb) comprised of an anti-CD3 monoclonal antibody heteroconjugated to an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, with potential antineoplastic and immunomodulating activities. Upon administration, anti-CD3 x anti-EGFR bispecific antibody-armed activated T-cells (AATC) attach to and selectively cross-link CD3-expressing T-cells and EGFR-expressing tumor cells. This results in the activation of cytotoxic T-lymphocytes (CTLs) and selective cytotoxicity towards the EGFR-expressing tumor cells. In addition, cytokine and chemokine secretion by the T-cells further activates the immune system, which leads to the recruitment and activation of CTLs, and additional CTL-mediated tumor-specific cell lysis. CD3 is part of the functional T-cell receptor (TCR) complex, which is necessary for antigen recognition by T-cells, and is required for signal transduction. EGFR, a receptor tyrosine kinase, is overexpressed on the surfaces of various tumor cell types." @default.
- NCIT_C125185 NCIT_NHC0 "C125185" @default.
- NCIT_C125185 NCIT_P106 "Cell" @default.
- NCIT_C125185 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125185 NCIT_P108 "Anti-CD3/Anti-EGFR-bispecific Monoclonal Antibody-armed Activated Autologous T-lymphocytes" @default.
- NCIT_C125185 NCIT_P208 "CL504004" @default.
- NCIT_C125185 NCIT_P329 "777682" @default.
- NCIT_C125185 NCIT_P330 "777682" @default.
- NCIT_C125185 NCIT_P399 "777682" @default.
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- NCIT_C125185 normalizedInformationContent "100" @default.
- NCIT_C125185 referenceCount "1" @default.
- NCIT_C125185 hasExactSynonym "Anti-CD3 x Anti-EGFR AATCs" @default.
- NCIT_C125185 hasExactSynonym "Anti-CD3 x Anti-EGFR BATs" @default.
- NCIT_C125185 hasExactSynonym "Anti-CD3 x Anti-EGFR-bispecific Antibody Armed Activated Autologous T-cells" @default.
- NCIT_C125185 hasExactSynonym "Anti-CD3/Anti-EGFR-bispecific Monoclonal Antibody-armed Activated Autologous T-lymphocytes" @default.
- NCIT_C125185 inSubset NCIT_C128784 @default.
- NCIT_C125185 inSubset NCIT_C176424 @default.
- NCIT_C125185 type Class @default.
- NCIT_C125185 isDefinedBy ncit.owl @default.
- NCIT_C125185 label "Anti-CD3/Anti-EGFR-bispecific Monoclonal Antibody-armed Activated Autologous T-lymphocytes" @default.
- NCIT_C125185 subClassOf NCIT_C125185 @default.
- NCIT_C125185 subClassOf NCIT_C129820 @default.
- NCIT_C125185 subClassOf NCIT_C129821 @default.
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- NCIT_C125185 subClassOf NCIT_C142078 @default.
- NCIT_C125185 subClassOf NCIT_C1908 @default.
- NCIT_C125185 subClassOf NCIT_C1909 @default.
- NCIT_C125185 subClassOf NCIT_C274 @default.
- NCIT_C125185 subClassOf NCIT_C28681 @default.
- NCIT_C125185 subClassOf NCIT_C307 @default.
- NCIT_C125185 subClassOf NCIT_C308 @default.