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- NCIT_C125392 IAO_0000115 "An oligomeric proanthocyanidin extracted from the latex produced by the tree Croton lechleri (Euphorbiaceae), with antidiarrheal, and potential antiviral and antimicrobial activities. Upon oral administration, crofelemer acts locally within the gastrointestinal (GI) tract by inhibiting both the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion (Cl-) channel and the calcium-activated Cl- channel (CaCC) expressed on the luminal surface of enterocytes. This inhibits the secretion of chloride ions into the intestinal lumen and prevents high volume water loss. By normalizing Cl- and water balance in the intestines, crofelemer relieves secretory diarrhea." @default.
- NCIT_C125392 NCIT_NHC0 "C125392" @default.
- NCIT_C125392 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125392 NCIT_P107 "Crofelemer" @default.
- NCIT_C125392 NCIT_P108 "Crofelemer" @default.
- NCIT_C125392 NCIT_P207 "C0214828" @default.
- NCIT_C125392 NCIT_P210 "148465-45-6" @default.
- NCIT_C125392 NCIT_P319 "PY79D6C8RX" @default.
- NCIT_C125392 NCIT_P322 "CTRP" @default.
- NCIT_C125392 NCIT_P322 "FDA" @default.
- NCIT_C125392 NCIT_P329 "786348" @default.
- NCIT_C125392 NCIT_P330 "786348" @default.
- NCIT_C125392 NCIT_P399 "786348" @default.
- NCIT_C125392 normalizedInformationContent "100" @default.
- NCIT_C125392 referenceCount "1" @default.
- NCIT_C125392 hasExactSynonym "CROFELEMER" @default.
- NCIT_C125392 hasExactSynonym "Crofelemer" @default.
- NCIT_C125392 hasExactSynonym "Fulyzaq" @default.
- NCIT_C125392 hasExactSynonym "SP 303" @default.
- NCIT_C125392 hasExactSynonym "SP-303" @default.
- NCIT_C125392 hasExactSynonym "Virend" @default.
- NCIT_C125392 inSubset NCIT_C116977 @default.
- NCIT_C125392 inSubset NCIT_C116978 @default.
- NCIT_C125392 inSubset NCIT_C176424 @default.
- NCIT_C125392 inSubset NCIT_C63923 @default.
- NCIT_C125392 type Class @default.
- NCIT_C125392 isDefinedBy ncit.owl @default.
- NCIT_C125392 label "Crofelemer" @default.
- NCIT_C125392 subClassOf NCIT_C125392 @default.
- NCIT_C125392 subClassOf NCIT_C1908 @default.
- NCIT_C125392 subClassOf NCIT_C1909 @default.
- NCIT_C125392 subClassOf NCIT_C266 @default.
- NCIT_C125392 subClassOf NCIT_C78276 @default.