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- NCIT_C125549 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of an anti-CD19 humanized monoclonal antibody conjugated, via a cleavable linker comprised of valine-alanine and maleimide, to a cytotoxic, cross-linking agent pyrrolobenzodiazepine (PBD) dimer, which targets DNA minor grooves, with potential antineoplastic activity. Upon administration, the monoclonal antibody portion of loncastuximab tesirine targets the cell surface antigen CD19 on various cancer cells. Upon antibody/antigen binding and internalization, the cytotoxic PBD moiety is released. The imine groups of the PBD moiety bind to the N2 positions of guanines on opposite strands of DNA. This induces interstrand cross-links in the minor groove of DNA and inhibits DNA replication, which inhibits the proliferation of CD19-overexpressing tumor cells. CD19, a transmembrane receptor and tumor-associated antigen (TAA), is expressed on a number of B-cell-derived cancers." @default.
- NCIT_C125549 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125549 NCIT_A7 NCIT_C38894 @default.
- NCIT_C125549 NCIT_NHC0 "C125549" @default.
- NCIT_C125549 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125549 NCIT_P107 "Loncastuximab Tesirine" @default.
- NCIT_C125549 NCIT_P108 "Loncastuximab Tesirine" @default.
- NCIT_C125549 NCIT_P208 "CL504277" @default.
- NCIT_C125549 NCIT_P210 "1879918-31-6" @default.
- NCIT_C125549 NCIT_P302 "adult patients with relapsed or refractory large B-cell lymphoma" @default.
- NCIT_C125549 NCIT_P319 "7K5O7P6QIU" @default.
- NCIT_C125549 NCIT_P322 "CTRP" @default.
- NCIT_C125549 NCIT_P322 "FDA" @default.
- NCIT_C125549 NCIT_P322 "GDC" @default.
- NCIT_C125549 NCIT_P329 "778954" @default.
- NCIT_C125549 NCIT_P330 "778954" @default.
- NCIT_C125549 NCIT_P375 "Loncastuximab Tesirine" @default.
- NCIT_C125549 NCIT_P399 "778954" @default.
- NCIT_C125549 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C125549 referenceCount "2" @default.
- NCIT_C125549 hasExactSynonym "ADC ADCT-402" @default.
- NCIT_C125549 hasExactSynonym "ADCT-402" @default.
- NCIT_C125549 hasExactSynonym "Anti-CD19 PBD-conjugate ADCT-402" @default.
- NCIT_C125549 hasExactSynonym "LONCASTUXIMAB TESIRINE" @default.
- NCIT_C125549 hasExactSynonym "Loncastuximab Tesirine" @default.
- NCIT_C125549 hasExactSynonym "Loncastuximab Tesirine-lpyl" @default.
- NCIT_C125549 hasExactSynonym "MT 2111" @default.
- NCIT_C125549 hasExactSynonym "MT-2111" @default.
- NCIT_C125549 hasExactSynonym "MT2111" @default.
- NCIT_C125549 hasExactSynonym "Zynlonta" @default.
- NCIT_C125549 inSubset NCIT_C116977 @default.
- NCIT_C125549 inSubset NCIT_C116978 @default.
- NCIT_C125549 inSubset NCIT_C128784 @default.
- NCIT_C125549 inSubset NCIT_C157711 @default.
- NCIT_C125549 inSubset NCIT_C157712 @default.
- NCIT_C125549 inSubset NCIT_C176424 @default.
- NCIT_C125549 inSubset NCIT_C177537 @default.
- NCIT_C125549 inSubset NCIT_C63923 @default.
- NCIT_C125549 type Class @default.
- NCIT_C125549 isDefinedBy ncit.owl @default.
- NCIT_C125549 label "Loncastuximab Tesirine" @default.
- NCIT_C125549 subClassOf NCIT_C125549 @default.
- NCIT_C125549 subClassOf NCIT_C129821 @default.
- NCIT_C125549 subClassOf NCIT_C129823 @default.
- NCIT_C125549 subClassOf NCIT_C1512 @default.
- NCIT_C125549 subClassOf NCIT_C163758 @default.
- NCIT_C125549 subClassOf NCIT_C1908 @default.
- NCIT_C125549 subClassOf NCIT_C1909 @default.
- NCIT_C125549 subClassOf NCIT_C198634 @default.
- NCIT_C125549 subClassOf NCIT_C198859 @default.
- NCIT_C125549 subClassOf NCIT_C274 @default.
- NCIT_C125549 subClassOf NCIT_C307 @default.
- NCIT_C125549 subClassOf NCIT_C308 @default.