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- NCIT_C125604 IAO_0000115 "A combination preparation of conjugated estrogens and the selective estrogen receptor modulator (SERM) bazedoxifene that can be used for hormone replacement purposes. The conjugated estrogens increase the diminishing levels of estrogen in menopausal and postmenopausal women by binding to and activating estrogen receptors (ERs), which, in turn, bind to estrogen response elements (EREs) in target genes; this results in the transcription of estrogen-regulated genes. Maintaining adequate estrogen levels decreases symptoms such as hot flashes, night sweats, irregular menstruation, fat redistribution, mood swings, sleep disorders, vaginal dryness and osteoporosis. Bazedoxifene specifically binds to and activates ERs in certain tissues, including liver, bone, breast, and endometrium, and also promotes the transcription of estrogen-regulated genes in these tissues. However, bazedoxifene acts as an estrogen antagonist in uterine and breast tissue, thereby blocking the proliferative effects of estrogen-binding to ER-positive cells in these tissues." @default.
- NCIT_C125604 NCIT_A7 NCIT_C38361 @default.
- NCIT_C125604 NCIT_NHC0 "C125604" @default.
- NCIT_C125604 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125604 NCIT_P107 "Conjugated Estrogens/Bazedoxifene" @default.
- NCIT_C125604 NCIT_P108 "Conjugated Estrogens/Bazedoxifene" @default.
- NCIT_C125604 NCIT_P207 "C3668765" @default.
- NCIT_C125604 NCIT_P322 "CTRP" @default.
- NCIT_C125604 NCIT_P329 "779789" @default.
- NCIT_C125604 NCIT_P330 "779789" @default.
- NCIT_C125604 NCIT_P399 "779789" @default.
- NCIT_C125604 normalizedInformationContent "100" @default.
- NCIT_C125604 referenceCount "1" @default.
- NCIT_C125604 hasExactSynonym "CE/BZA Formulation" @default.
- NCIT_C125604 hasExactSynonym "CE/BZA" @default.
- NCIT_C125604 hasExactSynonym "Conjugated Estrogens/Bazedoxifene" @default.
- NCIT_C125604 hasExactSynonym "Duavee" @default.
- NCIT_C125604 inSubset NCIT_C116977 @default.
- NCIT_C125604 inSubset NCIT_C116978 @default.
- NCIT_C125604 inSubset NCIT_C176424 @default.
- NCIT_C125604 type Class @default.
- NCIT_C125604 isDefinedBy ncit.owl @default.
- NCIT_C125604 label "Conjugated Estrogens/Bazedoxifene" @default.
- NCIT_C125604 subClassOf NCIT_C125604 @default.
- NCIT_C125604 subClassOf NCIT_C1908 @default.
- NCIT_C125604 subClassOf NCIT_C1909 @default.
- NCIT_C125604 subClassOf NCIT_C29629 @default.
- NCIT_C125604 subClassOf NCIT_C29731 @default.