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- NCIT_C125631 IAO_0000115 "A proprietary, live-attenuated, double-deleted (LADD) strain of the Gram-positive bacterium Listeria monocytogenes (Lm) encoding multiple, as of yet undisclosed, tumor-associated antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, opolimogene capmilisbac is taken up by antigen-presenting cells (APCs), including dendritic cells (DCs). The TAAs are subsequently expressed by the APCs and then processed and presented to the immune system by both major histocompatibility complex (MHC) class I and II molecules. This activates the immune system and leads to the recruitment and activation of cytotoxic T-lymphocytes (CTLs) against the TAA-expressing tumor cells, eventually resulting in tumor cell lysis. Two genes contributing to the virulence of Lm have been removed to minimize the risk of infection." @default.
- NCIT_C125631 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125631 NCIT_NHC0 "C125631" @default.
- NCIT_C125631 NCIT_P106 "Bacterium" @default.
- NCIT_C125631 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125631 NCIT_P107 "Opolimogene Capmilisbac" @default.
- NCIT_C125631 NCIT_P108 "Opolimogene Capmilisbac" @default.
- NCIT_C125631 NCIT_P208 "CL504330" @default.
- NCIT_C125631 NCIT_P319 "2O95SM11L5" @default.
- NCIT_C125631 NCIT_P322 "CTRP" @default.
- NCIT_C125631 NCIT_P322 "FDA" @default.
- NCIT_C125631 NCIT_P322 "GDC" @default.
- NCIT_C125631 NCIT_P329 "778079" @default.
- NCIT_C125631 NCIT_P330 "778079" @default.
- NCIT_C125631 NCIT_P375 "Live-attenuated Double-deleted Listeria monocytogenes Bacteria JNJ-64041809" @default.
- NCIT_C125631 NCIT_P375 "Opolimogene Capmilisbac" @default.
- NCIT_C125631 NCIT_P399 "778079" @default.
- NCIT_C125631 normalizedInformationContent "100" @default.
- NCIT_C125631 referenceCount "1" @default.
- NCIT_C125631 hasExactSynonym "ADU-741" @default.
- NCIT_C125631 hasExactSynonym "JNJ-64041809" @default.
- NCIT_C125631 hasExactSynonym "JNJ-809" @default.
- NCIT_C125631 hasExactSynonym "OPOLIMOGENE CAPMILISBAC" @default.
- NCIT_C125631 hasExactSynonym "Opolimogene Capmilisbac" @default.
- NCIT_C125631 inSubset NCIT_C116977 @default.
- NCIT_C125631 inSubset NCIT_C116978 @default.
- NCIT_C125631 inSubset NCIT_C128784 @default.
- NCIT_C125631 inSubset NCIT_C157711 @default.
- NCIT_C125631 inSubset NCIT_C157712 @default.
- NCIT_C125631 inSubset NCIT_C176424 @default.
- NCIT_C125631 inSubset NCIT_C177537 @default.
- NCIT_C125631 inSubset NCIT_C63923 @default.
- NCIT_C125631 type Class @default.
- NCIT_C125631 isDefinedBy ncit.owl @default.
- NCIT_C125631 label "Opolimogene Capmilisbac" @default.
- NCIT_C125631 subClassOf NCIT_C125631 @default.
- NCIT_C125631 subClassOf NCIT_C1908 @default.
- NCIT_C125631 subClassOf NCIT_C1909 @default.
- NCIT_C125631 subClassOf NCIT_C307 @default.
- NCIT_C125631 subClassOf NCIT_C308 @default.
- NCIT_C125631 subClassOf NCIT_C62761 @default.
- NCIT_C125631 subClassOf NCIT_C923 @default.
- NCIT_C125631 subClassOf NCIT_C96390 @default.
- NCIT_C125631 subClassOf NCIT_C97116 @default.