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- NCIT_C125653 IAO_0000115 "A hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine." @default.
- NCIT_C125653 NCIT_NHC0 "C125653" @default.
- NCIT_C125653 NCIT_P106 "Organic Chemical" @default.
- NCIT_C125653 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125653 NCIT_P108 "Vortioxetine Hydrobromide" @default.
- NCIT_C125653 NCIT_P207 "C3667599" @default.
- NCIT_C125653 NCIT_P210 "960203-27-4" @default.
- NCIT_C125653 NCIT_P319 "TKS641KOAY" @default.
- NCIT_C125653 NCIT_P322 "FDA" @default.
- NCIT_C125653 NCIT_P329 "778329" @default.
- NCIT_C125653 NCIT_P330 "778329" @default.
- NCIT_C125653 NCIT_P399 "778329" @default.
- NCIT_C125653 normalizedInformationContent "100" @default.
- NCIT_C125653 referenceCount "1" @default.
- NCIT_C125653 hasExactSynonym "1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl)piperazine Monohydrobromide" @default.
- NCIT_C125653 hasExactSynonym "Brintellix" @default.
- NCIT_C125653 hasExactSynonym "Piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)-, Hydrobromide (1:1)" @default.
- NCIT_C125653 hasExactSynonym "Trintellix" @default.
- NCIT_C125653 hasExactSynonym "VORTIOXETINE HYDROBROMIDE" @default.
- NCIT_C125653 hasExactSynonym "Vortioxetine Hydrobromide" @default.
- NCIT_C125653 inSubset NCIT_C176424 @default.
- NCIT_C125653 inSubset NCIT_C63923 @default.
- NCIT_C125653 type Class @default.
- NCIT_C125653 isDefinedBy ncit.owl @default.
- NCIT_C125653 label "Vortioxetine Hydrobromide" @default.
- NCIT_C125653 subClassOf NCIT_C125653 @default.
- NCIT_C125653 subClassOf NCIT_C1908 @default.
- NCIT_C125653 subClassOf NCIT_C1909 @default.
- NCIT_C125653 subClassOf NCIT_C265 @default.
- NCIT_C125653 subClassOf NCIT_C78272 @default.