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- NCIT_C125714 IAO_0000115 "An orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity. Upon administration, alvelestat binds to and inhibits the activity of human NE. This inhibits NE-mediated inflammatory responses, which may prevent lung inflammation and injury, and may improve lung function associated with NE-induced respiratory diseases. NE, a serine protease released by neutrophils during inflammation, is upregulated in a number of respiratory diseases." @default.
- NCIT_C125714 NCIT_A7 NCIT_C104198 @default.
- NCIT_C125714 NCIT_NHC0 "C125714" @default.
- NCIT_C125714 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125714 NCIT_P107 "Alvelestat" @default.
- NCIT_C125714 NCIT_P108 "Alvelestat" @default.
- NCIT_C125714 NCIT_P207 "C3489797" @default.
- NCIT_C125714 NCIT_P210 "848141-11-7" @default.
- NCIT_C125714 NCIT_P319 "6Y5629322X" @default.
- NCIT_C125714 NCIT_P322 "CTRP" @default.
- NCIT_C125714 NCIT_P322 "FDA" @default.
- NCIT_C125714 NCIT_P329 "778992" @default.
- NCIT_C125714 NCIT_P330 "778992" @default.
- NCIT_C125714 NCIT_P399 "778992" @default.
- NCIT_C125714 normalizedInformationContent "100" @default.
- NCIT_C125714 referenceCount "1" @default.
- NCIT_C125714 hasExactSynonym "6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide" @default.
- NCIT_C125714 hasExactSynonym "ALVELESTAT" @default.
- NCIT_C125714 hasExactSynonym "AZD 9668" @default.
- NCIT_C125714 hasExactSynonym "AZD-9668" @default.
- NCIT_C125714 hasExactSynonym "AZD9668" @default.
- NCIT_C125714 hasExactSynonym "Alvelestat" @default.
- NCIT_C125714 inSubset NCIT_C116977 @default.
- NCIT_C125714 inSubset NCIT_C116978 @default.
- NCIT_C125714 inSubset NCIT_C173381 @default.
- NCIT_C125714 inSubset NCIT_C173383 @default.
- NCIT_C125714 inSubset NCIT_C176424 @default.
- NCIT_C125714 inSubset NCIT_C63923 @default.
- NCIT_C125714 type Class @default.
- NCIT_C125714 isDefinedBy ncit.owl @default.
- NCIT_C125714 label "Alvelestat" @default.
- NCIT_C125714 subClassOf NCIT_C125714 @default.
- NCIT_C125714 subClassOf NCIT_C1908 @default.
- NCIT_C125714 subClassOf NCIT_C1909 @default.
- NCIT_C125714 subClassOf NCIT_C471 @default.
- NCIT_C125714 subClassOf NCIT_C783 @default.