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- NCIT_C125717 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of the humanized monoclonal antibody Z4681A conjugated, via a cleavable disulfide linker, to the cytotoxic DNA alkylating agent DGN462, which is an indolino-benzodiazepine dimer containing a mono-imine moiety, with potential antineoplastic activity. The monoclonal antibody portion of anti-CD33 monoclonal antibody-DGN462 conjugate IMGN779 specifically binds to the cell surface antigen CD33 expressed on myeloid leukemia cells; upon internalization, the DGN462 moiety is released, and covalently binds to and alkylates DNA, thereby causing cell cycle arrest, apoptosis and inhibition of cell growth in myeloid leukemia cells that express CD33. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and myeloid leukemia cells." @default.
- NCIT_C125717 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125717 NCIT_A7 NCIT_C97246 @default.
- NCIT_C125717 NCIT_NHC0 "C125717" @default.
- NCIT_C125717 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125717 NCIT_P107 "Anti-CD33 Antibody-drug Conjugate IMGN779" @default.
- NCIT_C125717 NCIT_P108 "Anti-CD33 Antibody-drug Conjugate IMGN779" @default.
- NCIT_C125717 NCIT_P208 "CL504373" @default.
- NCIT_C125717 NCIT_P319 "YE6R3UY9IV" @default.
- NCIT_C125717 NCIT_P322 "CTRP" @default.
- NCIT_C125717 NCIT_P322 "FDA" @default.
- NCIT_C125717 NCIT_P322 "GDC" @default.
- NCIT_C125717 NCIT_P329 "778810" @default.
- NCIT_C125717 NCIT_P330 "778810" @default.
- NCIT_C125717 NCIT_P375 "Anti-CD33 Antibody-drug Conjugate IMGN779" @default.
- NCIT_C125717 NCIT_P399 "778810" @default.
- NCIT_C125717 normalizedInformationContent "100" @default.
- NCIT_C125717 referenceCount "1" @default.
- NCIT_C125717 hasExactSynonym "ADC IMGN779" @default.
- NCIT_C125717 hasExactSynonym "Anti-CD33 ADC IMGN779" @default.
- NCIT_C125717 hasExactSynonym "Anti-CD33 Antibody-drug Conjugate IMGN779" @default.
- NCIT_C125717 hasExactSynonym "IMGN-779" @default.
- NCIT_C125717 hasExactSynonym "IMGN779" @default.
- NCIT_C125717 inSubset NCIT_C116977 @default.
- NCIT_C125717 inSubset NCIT_C116978 @default.
- NCIT_C125717 inSubset NCIT_C128784 @default.
- NCIT_C125717 inSubset NCIT_C157711 @default.
- NCIT_C125717 inSubset NCIT_C157712 @default.
- NCIT_C125717 inSubset NCIT_C176424 @default.
- NCIT_C125717 inSubset NCIT_C177537 @default.
- NCIT_C125717 inSubset NCIT_C63923 @default.
- NCIT_C125717 type Class @default.
- NCIT_C125717 isDefinedBy ncit.owl @default.
- NCIT_C125717 label "Anti-CD33 Antibody-drug Conjugate IMGN779" @default.
- NCIT_C125717 subClassOf NCIT_C125717 @default.
- NCIT_C125717 subClassOf NCIT_C129821 @default.
- NCIT_C125717 subClassOf NCIT_C129823 @default.
- NCIT_C125717 subClassOf NCIT_C1512 @default.
- NCIT_C125717 subClassOf NCIT_C1908 @default.
- NCIT_C125717 subClassOf NCIT_C1909 @default.
- NCIT_C125717 subClassOf NCIT_C2333 @default.
- NCIT_C125717 subClassOf NCIT_C274 @default.
- NCIT_C125717 subClassOf NCIT_C307 @default.
- NCIT_C125717 subClassOf NCIT_C308 @default.