Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C125718> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- NCIT_C125718 IAO_0000115 "A soluble recombinant antibody-like fusion protein composed of the N-terminal CD47 binding domain of human signal-regulatory protein alpha (SIRPa) linked to the Fc domain of human immunoglobulin G1 (IgG1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, ontorpacept selectively targets and binds to CD47 expressed on tumor cells and blocks the interaction of CD47 with endogenous SIRPa, a cell surface protein expressed on macrophages. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of macrophage activation and phagocytosis of cancer cells. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein-1 (LRP-1), expressed on macrophages, and results in macrophage activation and the specific phagocytosis of tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, thereby allowing cancer cells to proliferate." @default.
- NCIT_C125718 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125718 NCIT_A7 NCIT_C25795 @default.
- NCIT_C125718 NCIT_NHC0 "C125718" @default.
- NCIT_C125718 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C125718 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125718 NCIT_P107 "Ontorpacept" @default.
- NCIT_C125718 NCIT_P108 "Ontorpacept" @default.
- NCIT_C125718 NCIT_P208 "CL504374" @default.
- NCIT_C125718 NCIT_P210 "2131089-46-6" @default.
- NCIT_C125718 NCIT_P319 "Q8A4U1Z9N2" @default.
- NCIT_C125718 NCIT_P322 "CTRP" @default.
- NCIT_C125718 NCIT_P322 "FDA" @default.
- NCIT_C125718 NCIT_P322 "GDC" @default.
- NCIT_C125718 NCIT_P375 "Ontorpacept" @default.
- NCIT_C125718 NCIT_P375 "SIRPa-Fc Fusion Protein TTI-621" @default.
- NCIT_C125718 normalizedInformationContent "100" @default.
- NCIT_C125718 referenceCount "1" @default.
- NCIT_C125718 hasExactSynonym "ONTORPACEPT" @default.
- NCIT_C125718 hasExactSynonym "Ontorpacept" @default.
- NCIT_C125718 hasExactSynonym "SIRPa-Fc Fusion Protein TTI-621" @default.
- NCIT_C125718 hasExactSynonym "SIRPaFc" @default.
- NCIT_C125718 hasExactSynonym "TTI 621" @default.
- NCIT_C125718 hasExactSynonym "TTI-621" @default.
- NCIT_C125718 inSubset NCIT_C116977 @default.
- NCIT_C125718 inSubset NCIT_C116978 @default.
- NCIT_C125718 inSubset NCIT_C128784 @default.
- NCIT_C125718 inSubset NCIT_C157711 @default.
- NCIT_C125718 inSubset NCIT_C157712 @default.
- NCIT_C125718 inSubset NCIT_C177537 @default.
- NCIT_C125718 inSubset NCIT_C63923 @default.
- NCIT_C125718 type Class @default.
- NCIT_C125718 isDefinedBy ncit.owl @default.
- NCIT_C125718 label "Ontorpacept" @default.
- NCIT_C125718 subClassOf NCIT_C125718 @default.
- NCIT_C125718 subClassOf NCIT_C129820 @default.
- NCIT_C125718 subClassOf NCIT_C141144 @default.
- NCIT_C125718 subClassOf NCIT_C163758 @default.
- NCIT_C125718 subClassOf NCIT_C1908 @default.
- NCIT_C125718 subClassOf NCIT_C1909 @default.
- NCIT_C125718 subClassOf NCIT_C192655 @default.
- NCIT_C125718 subClassOf NCIT_C274 @default.
- NCIT_C125718 subClassOf NCIT_C307 @default.
- NCIT_C125718 subClassOf NCIT_C308 @default.