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- NCIT_C125739 IAO_0000115 "An inhibitor of the bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon administration, the BRD4 inhibitor PLX51107 binds to the acetylated lysine recognition motifs in the bromodomains of the BRD4 protein, thereby preventing the binding of BRD4 to acetylated lysines on histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an induction of apoptosis and an inhibition of proliferation in BRD4-overexpressing tumor cells. BRD4, a member of the human bromodomain and extra-terminal (BET) family of proteins, is a transcriptional regulator that is overexpressed in certain tumor cells and plays an important role in cellular proliferation." @default.
- NCIT_C125739 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125739 NCIT_A7 NCIT_C92704 @default.
- NCIT_C125739 NCIT_NHC0 "C125739" @default.
- NCIT_C125739 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125739 NCIT_P107 "BRD4 Inhibitor PLX51107" @default.
- NCIT_C125739 NCIT_P108 "BRD4 Inhibitor PLX51107" @default.
- NCIT_C125739 NCIT_P208 "CL504394" @default.
- NCIT_C125739 NCIT_P210 "1627929-55-8" @default.
- NCIT_C125739 NCIT_P319 "W758F1L9ND" @default.
- NCIT_C125739 NCIT_P322 "CTRP" @default.
- NCIT_C125739 NCIT_P322 "FDA" @default.
- NCIT_C125739 NCIT_P322 "GDC" @default.
- NCIT_C125739 NCIT_P329 "779000" @default.
- NCIT_C125739 NCIT_P330 "779000" @default.
- NCIT_C125739 NCIT_P375 "BRD4 Inhibitor PLX51107" @default.
- NCIT_C125739 NCIT_P399 "779000" @default.
- NCIT_C125739 normalizedInformationContent "100" @default.
- NCIT_C125739 referenceCount "1" @default.
- NCIT_C125739 hasExactSynonym "BRD4 Inhibitor PLX51107" @default.
- NCIT_C125739 hasExactSynonym "PLX 51107" @default.
- NCIT_C125739 hasExactSynonym "PLX-51107" @default.
- NCIT_C125739 hasExactSynonym "PLX51107" @default.
- NCIT_C125739 inSubset NCIT_C116977 @default.
- NCIT_C125739 inSubset NCIT_C116978 @default.
- NCIT_C125739 inSubset NCIT_C128784 @default.
- NCIT_C125739 inSubset NCIT_C157711 @default.
- NCIT_C125739 inSubset NCIT_C157712 @default.
- NCIT_C125739 inSubset NCIT_C176424 @default.
- NCIT_C125739 inSubset NCIT_C177537 @default.
- NCIT_C125739 inSubset NCIT_C63923 @default.
- NCIT_C125739 type Class @default.
- NCIT_C125739 isDefinedBy ncit.owl @default.
- NCIT_C125739 label "BRD4 Inhibitor PLX51107" @default.
- NCIT_C125739 subClassOf NCIT_C125739 @default.
- NCIT_C125739 subClassOf NCIT_C128462 @default.
- NCIT_C125739 subClassOf NCIT_C129824 @default.
- NCIT_C125739 subClassOf NCIT_C1908 @default.
- NCIT_C125739 subClassOf NCIT_C1909 @default.
- NCIT_C125739 subClassOf NCIT_C2189 @default.
- NCIT_C125739 subClassOf NCIT_C274 @default.