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- NCIT_C1258 IAO_0000115 "A synthetic dihydrotriazine derivative with antineoplastic properties. As an antifolate agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate reductase (DHFR), resulting in decreased tetrahydrofolate production and interference with thymidylate synthesis. Unlike MTX, this agent is not converted to polyglutamate forms. Triazinate also inhibits the transport of folates and may be selectively toxic to MTX-resistant tumor cells. (NCI04)" @default.
- NCIT_C1258 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1258 NCIT_NHC0 "C1258" @default.
- NCIT_C1258 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1258 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1258 NCIT_P108 "Triazinate" @default.
- NCIT_C1258 NCIT_P175 "139105" @default.
- NCIT_C1258 NCIT_P207 "C0077008" @default.
- NCIT_C1258 NCIT_P210 "41191-04-2" @default.
- NCIT_C1258 NCIT_P319 "DD99Y262WC" @default.
- NCIT_C1258 NCIT_P322 "FDA" @default.
- NCIT_C1258 NCIT_P322 "GDC" @default.
- NCIT_C1258 NCIT_P329 "39162" @default.
- NCIT_C1258 NCIT_P330 "39162" @default.
- NCIT_C1258 NCIT_P366 "Triazinate" @default.
- NCIT_C1258 NCIT_P375 "Triazinate" @default.
- NCIT_C1258 NCIT_P399 "39162" @default.
- NCIT_C1258 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C1258 referenceCount "6" @default.
- NCIT_C1258 hasExactSynonym "BAF" @default.
- NCIT_C1258 hasExactSynonym "Baker's Antifol soluble" @default.
- NCIT_C1258 hasExactSynonym "Baker's Antifol" @default.
- NCIT_C1258 hasExactSynonym "Baker's Antifolate" @default.
- NCIT_C1258 hasExactSynonym "Bakers Antifol" @default.
- NCIT_C1258 hasExactSynonym "Bakers Antifolate" @default.
- NCIT_C1258 hasExactSynonym "Benzenesulfonyl fluoride, 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenyl]butyl]-, monoethanesulfonate (9CI)" @default.
- NCIT_C1258 hasExactSynonym "Ethanesulfonic Acid Compound" @default.
- NCIT_C1258 hasExactSynonym "Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1) (8CI)" @default.
- NCIT_C1258 hasExactSynonym "Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride" @default.
- NCIT_C1258 hasExactSynonym "Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3, 5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1) (9CI)" @default.
- NCIT_C1258 hasExactSynonym "Soluble Baker's Antifol" @default.
- NCIT_C1258 hasExactSynonym "TRIAZINATE" @default.
- NCIT_C1258 hasExactSynonym "TZT" @default.
- NCIT_C1258 hasExactSynonym "Triazinate" @default.
- NCIT_C1258 hasExactSynonym "alpha-(2-chloro-4-(4,6-diamino-2,2-dimethyl-s-trizin-1(2H)-yl)phenoxy)-N,N-dimethyl-m-toluamide ethanesulfonic acid" @default.
- NCIT_C1258 hasExactSynonym "benzenesulfonyl fluoride, 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenyl]butyl]-, monoethanesulfonate (9CI)" @default.
- NCIT_C1258 hasExactSynonym "ethanesulfonic acid compound with 3-((2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenoxy)methyl)-N,N-dimethylben zamide (1:1)" @default.
- NCIT_C1258 hasExactSynonym "ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1)(8CI)" @default.
- NCIT_C1258 hasExactSynonym "ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride" @default.
- NCIT_C1258 hasExactSynonym "ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3, 5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1)(9CI)" @default.
- NCIT_C1258 inSubset NCIT_C128784 @default.
- NCIT_C1258 inSubset NCIT_C157711 @default.
- NCIT_C1258 inSubset NCIT_C157712 @default.
- NCIT_C1258 inSubset NCIT_C176424 @default.
- NCIT_C1258 inSubset NCIT_C177537 @default.
- NCIT_C1258 inSubset NCIT_C63923 @default.
- NCIT_C1258 type Class @default.
- NCIT_C1258 isDefinedBy ncit.owl @default.
- NCIT_C1258 label "Triazinate" @default.
- NCIT_C1258 subClassOf NCIT_C1258 @default.
- NCIT_C1258 subClassOf NCIT_C186664 @default.
- NCIT_C1258 subClassOf NCIT_C1908 @default.
- NCIT_C1258 subClassOf NCIT_C1909 @default.
- NCIT_C1258 subClassOf NCIT_C2153 @default.
- NCIT_C1258 subClassOf NCIT_C272 @default.
- NCIT_C1258 subClassOf NCIT_C274 @default.
- NCIT_C1258 subClassOf NCIT_C471 @default.
- NCIT_C1258 subClassOf NCIT_C511 @default.