Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C125899> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- NCIT_C125899 IAO_0000115 "A cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Upon administration, dalpiciclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6). This inhibits retinoblastoma (Rb) protein phosphorylation early in the G1 phase, which prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression." @default.
- NCIT_C125899 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125899 NCIT_NHC0 "C125899" @default.
- NCIT_C125899 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125899 NCIT_P108 "Dalpiciclib" @default.
- NCIT_C125899 NCIT_P208 "CL504548" @default.
- NCIT_C125899 NCIT_P210 "1637781-04-4" @default.
- NCIT_C125899 NCIT_P319 "5ZHA5P4PFX" @default.
- NCIT_C125899 NCIT_P322 "FDA" @default.
- NCIT_C125899 NCIT_P322 "GDC" @default.
- NCIT_C125899 NCIT_P329 "778742" @default.
- NCIT_C125899 NCIT_P330 "778742" @default.
- NCIT_C125899 NCIT_P375 "CDK4/6 Inhibitor SHR6390" @default.
- NCIT_C125899 NCIT_P399 "778742" @default.
- NCIT_C125899 normalizedInformationContent "100" @default.
- NCIT_C125899 referenceCount "1" @default.
- NCIT_C125899 hasExactSynonym "CDK4/6 Inhibitor SHR6390" @default.
- NCIT_C125899 hasExactSynonym "DALPICICLIB" @default.
- NCIT_C125899 hasExactSynonym "Dalpiciclib" @default.
- NCIT_C125899 hasExactSynonym "SHR-6390" @default.
- NCIT_C125899 hasExactSynonym "SHR6390" @default.
- NCIT_C125899 inSubset NCIT_C128784 @default.
- NCIT_C125899 inSubset NCIT_C157711 @default.
- NCIT_C125899 inSubset NCIT_C157712 @default.
- NCIT_C125899 inSubset NCIT_C176424 @default.
- NCIT_C125899 inSubset NCIT_C177537 @default.
- NCIT_C125899 inSubset NCIT_C63923 @default.
- NCIT_C125899 type Class @default.
- NCIT_C125899 isDefinedBy ncit.owl @default.
- NCIT_C125899 label "Dalpiciclib" @default.
- NCIT_C125899 subClassOf NCIT_C125899 @default.
- NCIT_C125899 subClassOf NCIT_C129824 @default.
- NCIT_C125899 subClassOf NCIT_C129825 @default.
- NCIT_C125899 subClassOf NCIT_C1404 @default.
- NCIT_C125899 subClassOf NCIT_C163758 @default.
- NCIT_C125899 subClassOf NCIT_C1908 @default.
- NCIT_C125899 subClassOf NCIT_C1909 @default.
- NCIT_C125899 subClassOf NCIT_C192741 @default.
- NCIT_C125899 subClassOf NCIT_C192742 @default.
- NCIT_C125899 subClassOf NCIT_C2185 @default.
- NCIT_C125899 subClassOf NCIT_C2189 @default.
- NCIT_C125899 subClassOf NCIT_C274 @default.
- NCIT_C125899 subClassOf NCIT_C471 @default.
- NCIT_C125899 subClassOf NCIT_C61074 @default.