Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C125901> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- NCIT_C125901 IAO_0000115 "A synthetic conjugate composed of the bisphosphonate etidronate linked to the cytostatic agent and antimetabolite cytarabine, with potential antineoplastic and antiresorptive activities. Upon intravenous administration of the etidronate-cytarabine conjugate MBC-11, the etidronate moiety targets bone and the two moieties are released upon hydrolysis. Etidronate binds to hydroxyapatite crystals in bone tissues and prevents its resorption. This prevents bone destruction and induces bone cell mineralization. In addition, the bone-targeting nature of this agent allows for the accumulation of cytarabine in bone tissue, where it is able to exert its antitumor effect locally by competing with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis, while reducing systemic exposure. This leads to a destruction of bone-associated tumor cells, an inhibition of tumor cell proliferation and bone metastasis, and prevents tumor-mediated bone destruction." @default.
- NCIT_C125901 NCIT_A32 NCIT_C1909 @default.
- NCIT_C125901 NCIT_NHC0 "C125901" @default.
- NCIT_C125901 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125901 NCIT_P108 "Etidronate-Cytarabine Conjugate MBC-11" @default.
- NCIT_C125901 NCIT_P208 "CL504550" @default.
- NCIT_C125901 NCIT_P210 "332863-86-2" @default.
- NCIT_C125901 NCIT_P319 "4M53T688S5" @default.
- NCIT_C125901 NCIT_P322 "FDA" @default.
- NCIT_C125901 NCIT_P322 "GDC" @default.
- NCIT_C125901 NCIT_P329 "778808" @default.
- NCIT_C125901 NCIT_P330 "778808" @default.
- NCIT_C125901 NCIT_P375 "Etidronate-Cytarabine Conjugate MBC-11" @default.
- NCIT_C125901 NCIT_P399 "778808" @default.
- NCIT_C125901 normalizedInformationContent "100" @default.
- NCIT_C125901 referenceCount "1" @default.
- NCIT_C125901 hasExactSynonym "Etidronate-Cytarabine Conjugate MBC-11" @default.
- NCIT_C125901 hasExactSynonym "Etidronate-ara-C Conjugate MBC-11" @default.
- NCIT_C125901 hasExactSynonym "MBC-11" @default.
- NCIT_C125901 inSubset NCIT_C128784 @default.
- NCIT_C125901 inSubset NCIT_C157711 @default.
- NCIT_C125901 inSubset NCIT_C157712 @default.
- NCIT_C125901 inSubset NCIT_C176424 @default.
- NCIT_C125901 inSubset NCIT_C177537 @default.
- NCIT_C125901 inSubset NCIT_C63923 @default.
- NCIT_C125901 type Class @default.
- NCIT_C125901 isDefinedBy ncit.owl @default.
- NCIT_C125901 label "Etidronate-Cytarabine Conjugate MBC-11" @default.
- NCIT_C125901 subClassOf NCIT_C125901 @default.
- NCIT_C125901 subClassOf NCIT_C1557 @default.
- NCIT_C125901 subClassOf NCIT_C186664 @default.
- NCIT_C125901 subClassOf NCIT_C1908 @default.
- NCIT_C125901 subClassOf NCIT_C1909 @default.
- NCIT_C125901 subClassOf NCIT_C272 @default.
- NCIT_C125901 subClassOf NCIT_C274 @default.
- NCIT_C125901 subClassOf NCIT_C67439 @default.
- NCIT_C125901 subClassOf NCIT_C78281 @default.