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- NCIT_C125903 IAO_0000115 "A recombinant fusion protein composed of the extracellular domain of the mature human glycoprotein CD24 linked to a human immunoglobulin G1 (IgG1) Fc domain, with potential immune checkpoint inhibitory, anti-inflammatory and antineoplastic activities. Upon administration, efprezimod alfa binds to injured cell components, also called DAMPs (Danger-Associated Molecular Patterns), thereby preventing the interaction of DAMPs with toll-like receptors (TLRs) and inhibiting both nuclear factor-kappa B (NFkB) activation and secretion of inflammatory cytokines. In addition, efprezimod alfa binds to and activates Siglec G/10, a sialic acid-binding immunoglobulin-type lectin, and stimulates SHP-1-mediated inhibitory signaling, while also preventing NFkB activation and secretion of inflammatory mediators, which further prevents inflammatory responses. DAMPs activate the innate immune system. CD24 binds to both DAMPs and Siglec G/10 to regulate immune responses.CD24/Siglec G/10 interaction plays a key role in a number of immune-mediated diseases including graft-versus-host disease (GvHD), multiple sclerosis and rheumatoid arthritis." @default.
- NCIT_C125903 NCIT_A7 NCIT_C118474 @default.
- NCIT_C125903 NCIT_NHC0 "C125903" @default.
- NCIT_C125903 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C125903 NCIT_P107 "Efprezimod Alfa" @default.
- NCIT_C125903 NCIT_P108 "Efprezimod Alfa" @default.
- NCIT_C125903 NCIT_P208 "CL504552" @default.
- NCIT_C125903 NCIT_P210 "2574508-57-7" @default.
- NCIT_C125903 NCIT_P319 "FN12T66RMN" @default.
- NCIT_C125903 NCIT_P322 "CTRP" @default.
- NCIT_C125903 NCIT_P322 "FDA" @default.
- NCIT_C125903 NCIT_P329 "778856" @default.
- NCIT_C125903 NCIT_P330 "778856" @default.
- NCIT_C125903 NCIT_P399 "778856" @default.
- NCIT_C125903 normalizedInformationContent "100" @default.
- NCIT_C125903 referenceCount "1" @default.
- NCIT_C125903 hasExactSynonym "CD24 Extracellular Domain-IgG1 Fc Domain Recombinant Fusion Protein CD24Fc" @default.
- NCIT_C125903 hasExactSynonym "CD24Fc CD24IgG" @default.
- NCIT_C125903 hasExactSynonym "CD24Fc" @default.
- NCIT_C125903 hasExactSynonym "EFPREZIMOD ALFA" @default.
- NCIT_C125903 hasExactSynonym "Efprezimod Alfa" @default.
- NCIT_C125903 hasExactSynonym "MK-7110" @default.
- NCIT_C125903 hasExactSynonym "SACCOVID" @default.
- NCIT_C125903 inSubset NCIT_C116977 @default.
- NCIT_C125903 inSubset NCIT_C116978 @default.
- NCIT_C125903 inSubset NCIT_C128784 @default.
- NCIT_C125903 inSubset NCIT_C173381 @default.
- NCIT_C125903 inSubset NCIT_C173383 @default.
- NCIT_C125903 inSubset NCIT_C176424 @default.
- NCIT_C125903 inSubset NCIT_C63923 @default.
- NCIT_C125903 type Class @default.
- NCIT_C125903 isDefinedBy ncit.owl @default.
- NCIT_C125903 label "Efprezimod Alfa" @default.
- NCIT_C125903 subClassOf NCIT_C125903 @default.
- NCIT_C125903 subClassOf NCIT_C141144 @default.
- NCIT_C125903 subClassOf NCIT_C1908 @default.
- NCIT_C125903 subClassOf NCIT_C1909 @default.
- NCIT_C125903 subClassOf NCIT_C308 @default.