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- NCIT_C126269 IAO_0000115 "A radioconjugate composed of a camelid single domain antibody (sdAb) CAM-H2 (VHH1; sdAb 2Rs 15d) directed against human epidermal growth factor receptor 2 (HER2, EGFR2, ERBB2) that is covalently linked via N-succinimidyl 4-guanidinomethyl-3-iodobenzoate (SGMIB) to the radionuclide iodine I 131, with radioimaging and antineoplastic activities. Upon administration of iodine I 131 SGMIB-anti-HER2 CAM-H2, the anti-HER2 antibody moiety targets and binds to HER2-expressing cells. This facilitates both the detection of HER2-expressing tumor cells and the targeted destruction of HER2-positive tumors. HER2, a tyrosine kinase is overexpressed on the cell surfaces of various tumor cell types. CAM-H2 is composed of small (15 kDa), heavy chain-only anti-HER2 antibody fragments that are able to cross the blood-brain barrier (BBB) and are thus potentially useful in the treatment of central nervous system (CNS) metastases." @default.
- NCIT_C126269 NCIT_A7 NCIT_C17319 @default.
- NCIT_C126269 NCIT_NHC0 "C126269" @default.
- NCIT_C126269 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C126269 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126269 NCIT_P107 "Iodine I 131 SGMIB-Anti-HER2 CAM-H2" @default.
- NCIT_C126269 NCIT_P108 "Iodine I 131 SGMIB-Anti-HER2 CAM-H2" @default.
- NCIT_C126269 NCIT_P208 "CL504846" @default.
- NCIT_C126269 NCIT_P322 "CTRP" @default.
- NCIT_C126269 NCIT_P322 "GDC" @default.
- NCIT_C126269 NCIT_P329 "778997" @default.
- NCIT_C126269 NCIT_P330 "778997" @default.
- NCIT_C126269 NCIT_P399 "778997" @default.
- NCIT_C126269 normalizedInformationContent "100" @default.
- NCIT_C126269 referenceCount "1" @default.
- NCIT_C126269 hasExactSynonym "I-131-CAM H2" @default.
- NCIT_C126269 hasExactSynonym "I-131-CAM-H2" @default.
- NCIT_C126269 hasExactSynonym "I-131-CAMH2" @default.
- NCIT_C126269 hasExactSynonym "I-131-VHH1" @default.
- NCIT_C126269 hasExactSynonym "Iodine I 131 N-succinimidyl 4-guanidinomethyl-3-iodobenzoate-Anti-HER2 VHH1" @default.
- NCIT_C126269 hasExactSynonym "Iodine I 131 SGMIB-Anti-HER2 CAM-H2" @default.
- NCIT_C126269 hasExactSynonym "Iodine I 131 SGMIB-Anti-HER2 VHH1" @default.
- NCIT_C126269 hasExactSynonym "Iodine I 131 SGMIB-Anti-HER2 sdAb 2Rs 15d" @default.
- NCIT_C126269 hasExactSynonym "[131I]-SGMIB Anti-HER2 VHH1" @default.
- NCIT_C126269 inSubset NCIT_C116977 @default.
- NCIT_C126269 inSubset NCIT_C116978 @default.
- NCIT_C126269 inSubset NCIT_C128784 @default.
- NCIT_C126269 inSubset NCIT_C157711 @default.
- NCIT_C126269 inSubset NCIT_C157712 @default.
- NCIT_C126269 inSubset NCIT_C176424 @default.
- NCIT_C126269 type Class @default.
- NCIT_C126269 isDefinedBy ncit.owl @default.
- NCIT_C126269 label "Iodine I 131 SGMIB-Anti-HER2 CAM-H2" @default.
- NCIT_C126269 subClassOf NCIT_C126269 @default.
- NCIT_C126269 subClassOf NCIT_C1446 @default.
- NCIT_C126269 subClassOf NCIT_C1511 @default.
- NCIT_C126269 subClassOf NCIT_C1512 @default.
- NCIT_C126269 subClassOf NCIT_C1908 @default.
- NCIT_C126269 subClassOf NCIT_C1909 @default.
- NCIT_C126269 subClassOf NCIT_C2124 @default.
- NCIT_C126269 subClassOf NCIT_C307 @default.
- NCIT_C126269 subClassOf NCIT_C308 @default.