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- NCIT_C126276 IAO_0000115 "A fusion protein consisting of a peptide sequence of human papillomavirus (HPV) type 16 E7 nuclear protein and fused to the Pseudomonas aeruginosa exotoxin A (PE) and a endoplasmic reticulum (ER) retention signal (KDEL), with potential antineoplastic activity. Upon administration of PE/HPV16 E7/KDEL fusion protein TVGV-1, the PE moiety binds to CD91 (LRP1) expressed on a variety of cells, including antigen-presenting cells such as dendritic cells (DCs), which facilitates the internalization, through endocytosis, of TVGV-1. Following endocytosis, this agent is proteolytically cleaved by the proteasome and the epitopes from the HPV E7 protein become bound to MHC-I molecules and are presented on the DC-cell surface. This facilitates a cytotoxic T-cell- mediated immune response against HPV16 E7 expressing-tumor cells. KDEL targets the fusion protein to the ER, which increases this agent's potential to be bound by MHC-I molecules; this increases the immune response against HPV16 E7-expressing cancer cells." @default.
- NCIT_C126276 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126276 NCIT_A7 NCIT_C1179 @default.
- NCIT_C126276 NCIT_NHC0 "C126276" @default.
- NCIT_C126276 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126276 NCIT_P107 "PE/HPV16 E7/KDEL Fusion Protein/GPI-0100 TVGV-1" @default.
- NCIT_C126276 NCIT_P108 "PE/HPV16 E7/KDEL Fusion Protein/GPI-0100 TVGV-1" @default.
- NCIT_C126276 NCIT_P208 "CL504853" @default.
- NCIT_C126276 NCIT_P322 "CTRP" @default.
- NCIT_C126276 NCIT_P322 "GDC" @default.
- NCIT_C126276 NCIT_P329 "779306" @default.
- NCIT_C126276 NCIT_P330 "779306" @default.
- NCIT_C126276 NCIT_P375 "PE/HPV16 E7/KDEL Fusion Protein/GPI-0100 TVGV-1" @default.
- NCIT_C126276 NCIT_P399 "779306" @default.
- NCIT_C126276 normalizedInformationContent "100" @default.
- NCIT_C126276 referenceCount "1" @default.
- NCIT_C126276 hasExactSynonym "PE-E7-KDEL/GPI-0100 TVGV-1" @default.
- NCIT_C126276 hasExactSynonym "PE/HPV16 E7/KDEL Fusion Protein/GPI-0100 TVGV-1" @default.
- NCIT_C126276 hasExactSynonym "PEK Fusion Protein/GPI-0100 Vaccine" @default.
- NCIT_C126276 hasExactSynonym "TVGV-1 Vaccine" @default.
- NCIT_C126276 hasExactSynonym "TVGV-1" @default.
- NCIT_C126276 inSubset NCIT_C116977 @default.
- NCIT_C126276 inSubset NCIT_C116978 @default.
- NCIT_C126276 inSubset NCIT_C128784 @default.
- NCIT_C126276 inSubset NCIT_C157711 @default.
- NCIT_C126276 inSubset NCIT_C157712 @default.
- NCIT_C126276 inSubset NCIT_C176424 @default.
- NCIT_C126276 inSubset NCIT_C177537 @default.
- NCIT_C126276 type Class @default.
- NCIT_C126276 isDefinedBy ncit.owl @default.
- NCIT_C126276 label "PE/HPV16 E7/KDEL Fusion Protein/GPI-0100 TVGV-1" @default.
- NCIT_C126276 subClassOf NCIT_C126276 @default.
- NCIT_C126276 subClassOf NCIT_C1908 @default.
- NCIT_C126276 subClassOf NCIT_C1909 @default.
- NCIT_C126276 subClassOf NCIT_C308 @default.
- NCIT_C126276 subClassOf NCIT_C574 @default.