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- NCIT_C126277 IAO_0000115 "A fluorescence imaging agent composed of a fluorescent agent linked, via a human neutrophil elastase (HNE) cleavable peptide, to a dequencher molecule, with imaging activity for diagnostic purposes. Upon local administration, the neutrophil activation probe (NAP) imaging agent, initially quenched, is quickly taken up by activated neutrophils. In turn, the HNE expressed by these cells, specifically cleaves the linker and dequenches the fluorescent agent. The activated fluorescent moiety allows for visualization of activated neutrophils and HNE activity upon using a fluorescence imaging device. Activated neutrophils are upregulated at sites of inflammation and in inflammation-induced cancers, and express high levels of HNE." @default.
- NCIT_C126277 NCIT_NHC0 "C126277" @default.
- NCIT_C126277 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C126277 NCIT_P108 "Neutrophil Activation Probe Imaging Agent" @default.
- NCIT_C126277 NCIT_P208 "CL504854" @default.
- NCIT_C126277 NCIT_P329 "779307" @default.
- NCIT_C126277 NCIT_P330 "779307" @default.
- NCIT_C126277 NCIT_P399 "779307" @default.
- NCIT_C126277 normalizedInformationContent "100" @default.
- NCIT_C126277 referenceCount "1" @default.
- NCIT_C126277 hasExactSynonym "NAP Imaging Agent" @default.
- NCIT_C126277 hasExactSynonym "NAP" @default.
- NCIT_C126277 hasExactSynonym "Neutrophil Activation Probe Imaging Agent" @default.
- NCIT_C126277 inSubset NCIT_C176424 @default.
- NCIT_C126277 type Class @default.
- NCIT_C126277 isDefinedBy ncit.owl @default.
- NCIT_C126277 label "Neutrophil Activation Probe Imaging Agent" @default.
- NCIT_C126277 subClassOf NCIT_C126277 @default.
- NCIT_C126277 subClassOf NCIT_C1908 @default.
- NCIT_C126277 subClassOf NCIT_C1966 @default.
- NCIT_C126277 subClassOf NCIT_C45678 @default.
- NCIT_C126277 subClassOf NCIT_C802 @default.