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- NCIT_C126333 IAO_0000115 "A suspension-based oral spray containing multilamellar lipid vesicles in which the lipids mimic the lipidic composition of endogenous extra-alveolar lamellar bodies, with muco-restorative and protective activity against radiotherapy (RT)-induced xerostomia (RIX). Upon sublingual administration of the lamellar body mimetic LMS-611 using a spray, the lipids in this agent mimic the natural secretions of endogenous lamellar bodies. This makes mucus more fluid and may prevent dryness of the mouth. This restores saliva functions and makes it easier to chew, swallow and talk, and also prevents xerostomia-induced infections, tooth decay and tooth enamel decay. RT decreases saliva secretion by causing the destruction of the parotid and submandibular serous salivary glands and lamellar bodies. This results in thicker and more visco-adhesive saliva, which causes various xerostomia-induced symptoms; intact lamellar bodies maintain the fluidity of mucus and lubricate the mouth." @default.
- NCIT_C126333 NCIT_NHC0 "C126333" @default.
- NCIT_C126333 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126333 NCIT_P108 "Lamellar Body Mimetic Mouth Spray LMS-611" @default.
- NCIT_C126333 NCIT_P208 "CL504899" @default.
- NCIT_C126333 NCIT_P329 "779608" @default.
- NCIT_C126333 NCIT_P330 "779608" @default.
- NCIT_C126333 NCIT_P399 "779608" @default.
- NCIT_C126333 normalizedInformationContent "100" @default.
- NCIT_C126333 referenceCount "1" @default.
- NCIT_C126333 hasExactSynonym "LMS-611" @default.
- NCIT_C126333 hasExactSynonym "Lamellar Body Mimetic Mouth Spray LMS-611" @default.
- NCIT_C126333 hasExactSynonym "OXB/1-20" @default.
- NCIT_C126333 hasExactSynonym "RIX-LMS-611x-20" @default.
- NCIT_C126333 hasExactSynonym "Visco-ease" @default.
- NCIT_C126333 inSubset NCIT_C176424 @default.
- NCIT_C126333 type Class @default.
- NCIT_C126333 isDefinedBy ncit.owl @default.
- NCIT_C126333 label "Lamellar Body Mimetic Mouth Spray LMS-611" @default.
- NCIT_C126333 subClassOf NCIT_C126333 @default.
- NCIT_C126333 subClassOf NCIT_C1908 @default.
- NCIT_C126333 subClassOf NCIT_C1909 @default.
- NCIT_C126333 subClassOf NCIT_C26170 @default.
- NCIT_C126333 subClassOf NCIT_C797 @default.