Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C126355> ?p ?o ?g. }
Showing items 1 to 45 of
45
with 100 items per page.
- NCIT_C126355 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a bispecific antibody against the extracellular domain of human epidermal growth factor receptor 2 (HER2; ERBB2) comprised of the single-chain variable fragment (scFv) of the anti- HER2 monoclonal antibody trastuzumab, which binds to domain IV of HER2, fused to the heavy chains of the anti-HER2 monoclonal antibody 39S, which binds to domain II of HER2, and conjugated, via a cleavable linker, to the cytotoxic anti-microtubule agent tubulysin, with potential antineoplastic activity. Upon administration of ADC MEDI4276, the anti-HER2 bispecific antibody specifically targets and binds to HER2 on the surface of certain cancer cells. Upon binding, crosslinking and internalization of antibody-HER2 complexes occurs and MEDI4276 is transported to the lysosome where the linker is cleaved, thereby delivering tubulysin inside HER2-expressing cancer cells. Tubulysin binds to tubulin and inhibits microtubule polymerization, which blocks cell division. This results in G2/M phase arrest, tumor cell apoptosis, and decreased proliferation of HER2-expressing tumor cells. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types." @default.
- NCIT_C126355 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126355 NCIT_A7 NCIT_C17319 @default.
- NCIT_C126355 NCIT_NHC0 "C126355" @default.
- NCIT_C126355 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126355 NCIT_P107 "Anti-HER2 Antibody-drug Conjugate MEDI4276" @default.
- NCIT_C126355 NCIT_P108 "Anti-HER2 Antibody-drug Conjugate MEDI4276" @default.
- NCIT_C126355 NCIT_P208 "CL504915" @default.
- NCIT_C126355 NCIT_P319 "ZAM3L34SEW" @default.
- NCIT_C126355 NCIT_P322 "CTRP" @default.
- NCIT_C126355 NCIT_P322 "FDA" @default.
- NCIT_C126355 NCIT_P322 "GDC" @default.
- NCIT_C126355 NCIT_P329 "780016" @default.
- NCIT_C126355 NCIT_P330 "780016" @default.
- NCIT_C126355 NCIT_P375 "Anti-HER2 Antibody-drug Conjugate MEDI4276" @default.
- NCIT_C126355 NCIT_P399 "780016" @default.
- NCIT_C126355 normalizedInformationContent "100" @default.
- NCIT_C126355 referenceCount "1" @default.
- NCIT_C126355 hasExactSynonym "ADC MEDI4276" @default.
- NCIT_C126355 hasExactSynonym "Anti-HER2 Antibody-drug Conjugate MEDI4276" @default.
- NCIT_C126355 hasExactSynonym "MEDI-4276" @default.
- NCIT_C126355 hasExactSynonym "MEDI4276" @default.
- NCIT_C126355 inSubset NCIT_C116977 @default.
- NCIT_C126355 inSubset NCIT_C116978 @default.
- NCIT_C126355 inSubset NCIT_C128784 @default.
- NCIT_C126355 inSubset NCIT_C157711 @default.
- NCIT_C126355 inSubset NCIT_C157712 @default.
- NCIT_C126355 inSubset NCIT_C176424 @default.
- NCIT_C126355 inSubset NCIT_C177537 @default.
- NCIT_C126355 inSubset NCIT_C63923 @default.
- NCIT_C126355 type Class @default.
- NCIT_C126355 isDefinedBy ncit.owl @default.
- NCIT_C126355 label "Anti-HER2 Antibody-drug Conjugate MEDI4276" @default.
- NCIT_C126355 subClassOf NCIT_C126355 @default.
- NCIT_C126355 subClassOf NCIT_C129821 @default.
- NCIT_C126355 subClassOf NCIT_C129823 @default.
- NCIT_C126355 subClassOf NCIT_C1512 @default.
- NCIT_C126355 subClassOf NCIT_C155712 @default.
- NCIT_C126355 subClassOf NCIT_C163758 @default.
- NCIT_C126355 subClassOf NCIT_C163760 @default.
- NCIT_C126355 subClassOf NCIT_C1908 @default.
- NCIT_C126355 subClassOf NCIT_C1909 @default.
- NCIT_C126355 subClassOf NCIT_C274 @default.
- NCIT_C126355 subClassOf NCIT_C307 @default.
- NCIT_C126355 subClassOf NCIT_C308 @default.