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- NCIT_C126377 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of an anti-CD19 humanized monoclonal antibody (hBU12ec) with engineered cysteines (EC-mAb) conjugated, via a maleimidocaproyl-valine-alanine dipeptide protease-cleavable linker, to the cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer (SGD-1882), with potential antineoplastic activity. Upon administration of anti-CD19 ADC SGN-CD19B, the antibody moiety targets the cell surface antigen CD19, which is found on B-cell-derived cancers. Upon antibody/antigen binding, internalization and lysosome uptake, the cytotoxic PBD moiety is released. In turn, the imine groups of the PBD moiety bind to the N2 positions of guanines on opposite strands of DNA. This induces DNA strand breaks, inhibits DNA replication, leads to G2/M cell cycle arrest, induces cell death, and inhibits the proliferation of CD19-overexpressing tumor cells. CD19, a transmembrane receptor belonging to the immunoglobulin superfamily and a B-cell specific antigen, is expressed on B-cell-derived cancers. The cysteine engineering of the EC-mAb allows for a site-specific and stable conjugation of PBD to the antibody." @default.
- NCIT_C126377 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126377 NCIT_A7 NCIT_C38894 @default.
- NCIT_C126377 NCIT_NHC0 "C126377" @default.
- NCIT_C126377 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C126377 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126377 NCIT_P107 "Anti-CD19 Antibody-drug Conjugate SGN-CD19B" @default.
- NCIT_C126377 NCIT_P108 "Anti-CD19 Antibody-drug Conjugate SGN-CD19B" @default.
- NCIT_C126377 NCIT_P208 "CL504928" @default.
- NCIT_C126377 NCIT_P322 "CTRP" @default.
- NCIT_C126377 NCIT_P322 "GDC" @default.
- NCIT_C126377 NCIT_P329 "779706" @default.
- NCIT_C126377 NCIT_P330 "779706" @default.
- NCIT_C126377 NCIT_P375 "Anti-CD19 Antibody-drug Conjugate SGN-CD19B" @default.
- NCIT_C126377 NCIT_P399 "779706" @default.
- NCIT_C126377 normalizedInformationContent "100" @default.
- NCIT_C126377 referenceCount "1" @default.
- NCIT_C126377 hasExactSynonym "ADC SGN-CD19B" @default.
- NCIT_C126377 hasExactSynonym "Anti-CD19 Antibody-drug Conjugate SGN-CD19B" @default.
- NCIT_C126377 hasExactSynonym "SGN CD19B" @default.
- NCIT_C126377 hasExactSynonym "SGN-CD19B" @default.
- NCIT_C126377 inSubset NCIT_C116977 @default.
- NCIT_C126377 inSubset NCIT_C116978 @default.
- NCIT_C126377 inSubset NCIT_C128784 @default.
- NCIT_C126377 inSubset NCIT_C157711 @default.
- NCIT_C126377 inSubset NCIT_C157712 @default.
- NCIT_C126377 inSubset NCIT_C176424 @default.
- NCIT_C126377 inSubset NCIT_C177537 @default.
- NCIT_C126377 type Class @default.
- NCIT_C126377 isDefinedBy ncit.owl @default.
- NCIT_C126377 label "Anti-CD19 Antibody-drug Conjugate SGN-CD19B" @default.
- NCIT_C126377 subClassOf NCIT_C126377 @default.
- NCIT_C126377 subClassOf NCIT_C129821 @default.
- NCIT_C126377 subClassOf NCIT_C129823 @default.
- NCIT_C126377 subClassOf NCIT_C1512 @default.
- NCIT_C126377 subClassOf NCIT_C163758 @default.
- NCIT_C126377 subClassOf NCIT_C1908 @default.
- NCIT_C126377 subClassOf NCIT_C1909 @default.
- NCIT_C126377 subClassOf NCIT_C198634 @default.
- NCIT_C126377 subClassOf NCIT_C198859 @default.
- NCIT_C126377 subClassOf NCIT_C274 @default.
- NCIT_C126377 subClassOf NCIT_C307 @default.
- NCIT_C126377 subClassOf NCIT_C308 @default.