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- NCIT_C1265 IAO_0000115 "A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04)" @default.
- NCIT_C1265 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1265 NCIT_A6 NCIT_C1314 @default.
- NCIT_C1265 NCIT_NHC0 "C1265" @default.
- NCIT_C1265 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1265 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1265 NCIT_P108 "Trimetrexate Glucuronate" @default.
- NCIT_C1265 NCIT_P175 "352122" @default.
- NCIT_C1265 NCIT_P207 "C0077209" @default.
- NCIT_C1265 NCIT_P210 "82952-64-5" @default.
- NCIT_C1265 NCIT_P302 "Head and neck cancer; Metastatic colorectal adenocarcinoma; Non-small cell lung cancer; Osteogenic sarcoma; Pancreatic adenocarcinoma; Pneumocystitis carinii pneumonia" @default.
- NCIT_C1265 NCIT_P319 "L137U4A79K" @default.
- NCIT_C1265 NCIT_P322 "FDA" @default.
- NCIT_C1265 NCIT_P322 "GDC" @default.
- NCIT_C1265 NCIT_P325 "A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer." @default.
- NCIT_C1265 NCIT_P329 "39764" @default.
- NCIT_C1265 NCIT_P330 "39764" @default.
- NCIT_C1265 NCIT_P350 "C19H23N5O3.C6H10O7" @default.
- NCIT_C1265 NCIT_P366 "Trimetrexate_Glucuronate" @default.
- NCIT_C1265 NCIT_P375 "Trimetrexate Glucuronate" @default.
- NCIT_C1265 NCIT_P399 "39764" @default.
- NCIT_C1265 normalizedInformationContent "86.239998175184226" @default.
- NCIT_C1265 referenceCount "8" @default.
- NCIT_C1265 hasExactSynonym "2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronate" @default.
- NCIT_C1265 hasExactSynonym "Neutrexin" @default.
- NCIT_C1265 hasExactSynonym "TMTX" @default.
- NCIT_C1265 hasExactSynonym "TRIMETREXATE GLUCURONATE" @default.
- NCIT_C1265 hasExactSynonym "Trimetrexate Glucuronate" @default.
- NCIT_C1265 hasExactSynonym "trimetrexate glucuronate" @default.
- NCIT_C1265 inSubset NCIT_C128784 @default.
- NCIT_C1265 inSubset NCIT_C157711 @default.
- NCIT_C1265 inSubset NCIT_C157712 @default.
- NCIT_C1265 inSubset NCIT_C176424 @default.
- NCIT_C1265 inSubset NCIT_C177537 @default.
- NCIT_C1265 inSubset NCIT_C63923 @default.
- NCIT_C1265 type Class @default.
- NCIT_C1265 isDefinedBy ncit.owl @default.
- NCIT_C1265 label "Trimetrexate Glucuronate" @default.
- NCIT_C1265 subClassOf NCIT_C1265 @default.
- NCIT_C1265 subClassOf NCIT_C1908 @default.
- NCIT_C1265 subClassOf NCIT_C1909 @default.
- NCIT_C1265 subClassOf NCIT_C2153 @default.
- NCIT_C1265 subClassOf NCIT_C471 @default.