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- NCIT_C1266 IAO_0000115 "A nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen." @default.
- NCIT_C1266 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1266 NCIT_A5 NCIT_C1414 @default.
- NCIT_C1266 NCIT_NHC0 "C1266" @default.
- NCIT_C1266 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1266 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1266 NCIT_P108 "Trioxifene" @default.
- NCIT_C1266 NCIT_P207 "C0077238" @default.
- NCIT_C1266 NCIT_P210 "63619-84-1" @default.
- NCIT_C1266 NCIT_P319 "R0130F043H" @default.
- NCIT_C1266 NCIT_P322 "FDA" @default.
- NCIT_C1266 NCIT_P322 "GDC" @default.
- NCIT_C1266 NCIT_P329 "39726" @default.
- NCIT_C1266 NCIT_P330 "39726" @default.
- NCIT_C1266 NCIT_P350 "C30H31NO3" @default.
- NCIT_C1266 NCIT_P366 "Trioxifene" @default.
- NCIT_C1266 NCIT_P375 "Trioxifene" @default.
- NCIT_C1266 NCIT_P399 "39726" @default.
- NCIT_C1266 normalizedInformationContent "100" @default.
- NCIT_C1266 referenceCount "1" @default.
- NCIT_C1266 hasExactSynonym "(3,4-Dihydro-2-(4-methoxyphenyl)-1-naphthalenyl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl) Methanone" @default.
- NCIT_C1266 hasExactSynonym "TRIOXIFENE" @default.
- NCIT_C1266 hasExactSynonym "Trioxifene" @default.
- NCIT_C1266 inSubset NCIT_C128784 @default.
- NCIT_C1266 inSubset NCIT_C157711 @default.
- NCIT_C1266 inSubset NCIT_C157712 @default.
- NCIT_C1266 inSubset NCIT_C176424 @default.
- NCIT_C1266 inSubset NCIT_C177537 @default.
- NCIT_C1266 inSubset NCIT_C63923 @default.
- NCIT_C1266 type Class @default.
- NCIT_C1266 isDefinedBy ncit.owl @default.
- NCIT_C1266 label "Trioxifene" @default.
- NCIT_C1266 subClassOf NCIT_C1266 @default.
- NCIT_C1266 subClassOf NCIT_C129818 @default.
- NCIT_C1266 subClassOf NCIT_C147908 @default.
- NCIT_C1266 subClassOf NCIT_C163758 @default.
- NCIT_C1266 subClassOf NCIT_C1821 @default.
- NCIT_C1266 subClassOf NCIT_C1892 @default.
- NCIT_C1266 subClassOf NCIT_C1908 @default.
- NCIT_C1266 subClassOf NCIT_C1909 @default.
- NCIT_C1266 subClassOf NCIT_C274 @default.
- NCIT_C1266 subClassOf NCIT_C481 @default.
- NCIT_C1266 subClassOf NCIT_C483 @default.
- NCIT_C1266 subClassOf NCIT_C547 @default.
- NCIT_C1266 subClassOf NCIT_C548 @default.