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- NCIT_C126638 IAO_0000115 "A triphenylmethane-based dye and an inhibitor of nicotinamide adenine dinucleotide phosphate (NADP+) oxidase 4 (NOX4), with potential anti-invasive and anti-oxidative activities. Upon administration, imipramine blue (IB) inhibits the activity of NOX4 and prevents NOX4-mediated cell signaling. This prevents the formation of NOX4-mediated reactive oxygen species (ROS), abrogates the ROS-induced inhibition of protein tyrosine phosphatase (PTP) activation, and induces both G2/M cell cycle arrest and apoptosis. NOX4, an enzyme belonging to the NOX family of proteins, promotes the production of ROS and plays a key role in the suppression of PTP activation; it is upregulated in a variety of cancers." @default.
- NCIT_C126638 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126638 NCIT_A7 NCIT_C104572 @default.
- NCIT_C126638 NCIT_NHC0 "C126638" @default.
- NCIT_C126638 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126638 NCIT_P107 "Imipramine Blue" @default.
- NCIT_C126638 NCIT_P108 "Imipramine Blue" @default.
- NCIT_C126638 NCIT_P208 "CL505071" @default.
- NCIT_C126638 NCIT_P322 "CTRP" @default.
- NCIT_C126638 NCIT_P322 "GDC" @default.
- NCIT_C126638 NCIT_P375 "Imipramine Blue" @default.
- NCIT_C126638 normalizedInformationContent "100" @default.
- NCIT_C126638 referenceCount "1" @default.
- NCIT_C126638 hasExactSynonym "IB" @default.
- NCIT_C126638 hasExactSynonym "Imipramine Blue" @default.
- NCIT_C126638 inSubset NCIT_C116977 @default.
- NCIT_C126638 inSubset NCIT_C116978 @default.
- NCIT_C126638 inSubset NCIT_C128784 @default.
- NCIT_C126638 inSubset NCIT_C157711 @default.
- NCIT_C126638 inSubset NCIT_C157712 @default.
- NCIT_C126638 inSubset NCIT_C177537 @default.
- NCIT_C126638 type Class @default.
- NCIT_C126638 isDefinedBy ncit.owl @default.
- NCIT_C126638 label "Imipramine Blue" @default.
- NCIT_C126638 subClassOf NCIT_C126638 @default.
- NCIT_C126638 subClassOf NCIT_C1908 @default.
- NCIT_C126638 subClassOf NCIT_C1909 @default.
- NCIT_C126638 subClassOf NCIT_C471 @default.