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- NCIT_C126641 IAO_0000115 "An orally bioavailable inhibitor of cell division cycle 7 (cell division cycle 7-related protein kinase; CDC7), with potential antineoplastic activity. Upon administration, simurosertib binds to and inhibits CDC7; this prevents the initiation of DNA replication during mitosis, which causes cell cycle arrest and induces apoptosis. This inhibits cell growth in CDC7-overexpressing tumor cells. CDC7, a serine/threonine kinase and cell division cycle protein, is overexpressed in a variety of cancers and plays a key role in the activation of DNA replication and the regulation of cell cycle progression." @default.
- NCIT_C126641 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126641 NCIT_A7 NCIT_C28678 @default.
- NCIT_C126641 NCIT_NHC0 "C126641" @default.
- NCIT_C126641 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126641 NCIT_P107 "Simurosertib" @default.
- NCIT_C126641 NCIT_P108 "Simurosertib" @default.
- NCIT_C126641 NCIT_P208 "CL505074" @default.
- NCIT_C126641 NCIT_P210 "1330782-76-7" @default.
- NCIT_C126641 NCIT_P319 "LST350G3XU" @default.
- NCIT_C126641 NCIT_P322 "CTRP" @default.
- NCIT_C126641 NCIT_P322 "FDA" @default.
- NCIT_C126641 NCIT_P322 "GDC" @default.
- NCIT_C126641 NCIT_P329 "779700" @default.
- NCIT_C126641 NCIT_P330 "779700" @default.
- NCIT_C126641 NCIT_P375 "CDC7 Inhibitor TAK-931" @default.
- NCIT_C126641 NCIT_P375 "Simurosertib" @default.
- NCIT_C126641 NCIT_P399 "779700" @default.
- NCIT_C126641 normalizedInformationContent "100" @default.
- NCIT_C126641 referenceCount "1" @default.
- NCIT_C126641 hasExactSynonym "Cell Division Cycle 7 Inhibitor TAK-931" @default.
- NCIT_C126641 hasExactSynonym "SIMUROSERTIB" @default.
- NCIT_C126641 hasExactSynonym "Simurosertib" @default.
- NCIT_C126641 hasExactSynonym "TAK 931" @default.
- NCIT_C126641 hasExactSynonym "TAK-931" @default.
- NCIT_C126641 hasExactSynonym "Thieno(3,2-d)pyrimidin-4(3H)-one, 2-(2S)-1-Azabicyclo(2.2.2)oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-" @default.
- NCIT_C126641 inSubset NCIT_C116977 @default.
- NCIT_C126641 inSubset NCIT_C116978 @default.
- NCIT_C126641 inSubset NCIT_C128784 @default.
- NCIT_C126641 inSubset NCIT_C157711 @default.
- NCIT_C126641 inSubset NCIT_C157712 @default.
- NCIT_C126641 inSubset NCIT_C176424 @default.
- NCIT_C126641 inSubset NCIT_C177537 @default.
- NCIT_C126641 inSubset NCIT_C63923 @default.
- NCIT_C126641 type Class @default.
- NCIT_C126641 isDefinedBy ncit.owl @default.
- NCIT_C126641 label "Simurosertib" @default.
- NCIT_C126641 subClassOf NCIT_C126641 @default.
- NCIT_C126641 subClassOf NCIT_C1404 @default.
- NCIT_C126641 subClassOf NCIT_C1908 @default.
- NCIT_C126641 subClassOf NCIT_C1909 @default.
- NCIT_C126641 subClassOf NCIT_C471 @default.
- NCIT_C126641 subClassOf NCIT_C61074 @default.