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- NCIT_C126642 IAO_0000115 "A sustained-release (SR) hydrogel polymer-based formulation containing the antineoplastic antibiotic mitomycin C (MMC), with potential antineoplastic activity. Upon local administration of the SR MMC hydrogel formulation to the upper urinary tract via a ureteral catheter, the gel solidifies and deposits MMC locally to prevent the excretion of this chemotherapeutic agent via urinary flow. In turn, MMC alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Due to its reverse thermal-gelation properties, this gel is able to stay in a liquid state at cold temperatures and solidifies at body temperature. This allows for increased accumulation of MMC locally in the upper urinary tract which leads to increased efficacy compared to standard intravesical delivery of MMC for upper tract urothelial carcinoma (UTUC)." @default.
- NCIT_C126642 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126642 NCIT_NHC0 "C126642" @default.
- NCIT_C126642 NCIT_P106 "Antibiotic" @default.
- NCIT_C126642 NCIT_P106 "Organic Chemical" @default.
- NCIT_C126642 NCIT_P107 "Sustained-release Mitomycin C Hydrogel Formulation UGN-101" @default.
- NCIT_C126642 NCIT_P108 "Sustained-release Mitomycin C Hydrogel Formulation UGN-101" @default.
- NCIT_C126642 NCIT_P208 "CL503759" @default.
- NCIT_C126642 NCIT_P322 "CTRP" @default.
- NCIT_C126642 NCIT_P322 "GDC" @default.
- NCIT_C126642 NCIT_P329 "779705" @default.
- NCIT_C126642 NCIT_P330 "779705" @default.
- NCIT_C126642 NCIT_P375 "Sustained-release Mitomycin C Hydrogel Formulation UGN-101" @default.
- NCIT_C126642 NCIT_P399 "779705" @default.
- NCIT_C126642 normalizedInformationContent "100" @default.
- NCIT_C126642 referenceCount "1" @default.
- NCIT_C126642 hasExactSynonym "MP77-08" @default.
- NCIT_C126642 hasExactSynonym "Mitogel" @default.
- NCIT_C126642 hasExactSynonym "RTGel with MMC" @default.
- NCIT_C126642 hasExactSynonym "RTGel with Mitomycin C" @default.
- NCIT_C126642 hasExactSynonym "SR Mitomycin C" @default.
- NCIT_C126642 hasExactSynonym "Sustained-release Mitomycin C Gel Formulation" @default.
- NCIT_C126642 hasExactSynonym "Sustained-release Mitomycin C Hydrogel Formulation UGN-101" @default.
- NCIT_C126642 hasExactSynonym "Sustained-release Mitomycin C Hydrogel Formulation" @default.
- NCIT_C126642 hasExactSynonym "UGN-101" @default.
- NCIT_C126642 inSubset NCIT_C116977 @default.
- NCIT_C126642 inSubset NCIT_C116978 @default.
- NCIT_C126642 inSubset NCIT_C128784 @default.
- NCIT_C126642 inSubset NCIT_C157711 @default.
- NCIT_C126642 inSubset NCIT_C157712 @default.
- NCIT_C126642 inSubset NCIT_C176424 @default.
- NCIT_C126642 inSubset NCIT_C177537 @default.
- NCIT_C126642 type Class @default.
- NCIT_C126642 isDefinedBy ncit.owl @default.
- NCIT_C126642 label "Sustained-release Mitomycin C Hydrogel Formulation UGN-101" @default.
- NCIT_C126642 subClassOf NCIT_C126642 @default.
- NCIT_C126642 subClassOf NCIT_C1590 @default.
- NCIT_C126642 subClassOf NCIT_C186664 @default.
- NCIT_C126642 subClassOf NCIT_C1908 @default.
- NCIT_C126642 subClassOf NCIT_C1909 @default.
- NCIT_C126642 subClassOf NCIT_C259 @default.
- NCIT_C126642 subClassOf NCIT_C274 @default.
- NCIT_C126642 subClassOf NCIT_C2842 @default.
- NCIT_C126642 subClassOf NCIT_C292 @default.
- NCIT_C126642 subClassOf NCIT_C663 @default.