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- NCIT_C126643 IAO_0000115 "An anti-human glucocorticoid-induced tumor necrosis factor receptor (tumor necrosis factor superfamily, member 18; TNFRSF18; GITR; CD357) agonistic humanized monoclonal antibody, with potential immune checkpoint modulating activity. Ragifilimab binds to and activates GITRs found on multiple types of T-cells. This stimulates the immune system, induces both the activation and proliferation of tumor-antigen-specific T effector cells (Teff), and suppresses the function of activated T regulatory cells (Tregs). This leads to tumor cell eradication. GITR, a member of the TNF receptor superfamily and T-cell receptor co-stimulator, is expressed on the surface of multiple immune cell types, including Tregs, Teffs, B-cells, and natural killer (NK) cells. Inappropriately activated Tregs suppress Teffs and suppress T-cell receptor (TCR) signaling." @default.
- NCIT_C126643 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126643 NCIT_A7 NCIT_C105568 @default.
- NCIT_C126643 NCIT_NHC0 "C126643" @default.
- NCIT_C126643 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126643 NCIT_P107 "Ragifilimab" @default.
- NCIT_C126643 NCIT_P108 "Ragifilimab" @default.
- NCIT_C126643 NCIT_P208 "CL503760" @default.
- NCIT_C126643 NCIT_P210 "2207590-51-8" @default.
- NCIT_C126643 NCIT_P319 "O440IW9NHN" @default.
- NCIT_C126643 NCIT_P322 "CTRP" @default.
- NCIT_C126643 NCIT_P322 "FDA" @default.
- NCIT_C126643 NCIT_P322 "GDC" @default.
- NCIT_C126643 NCIT_P329 "779746" @default.
- NCIT_C126643 NCIT_P330 "779746" @default.
- NCIT_C126643 NCIT_P375 "Anti-GITR Agonistic Monoclonal Antibody INCAGN01876" @default.
- NCIT_C126643 NCIT_P375 "Ragifilimab" @default.
- NCIT_C126643 NCIT_P399 "779746" @default.
- NCIT_C126643 NCIT_R124 NCIT_C17710 @default.
- NCIT_C126643 NCIT_R124 NCIT_C17828 @default.
- NCIT_C126643 NCIT_R124 NCIT_C18219 @default.
- NCIT_C126643 NCIT_R124 NCIT_C19986 @default.
- NCIT_C126643 NCIT_R124 NCIT_C40474 @default.
- NCIT_C126643 normalizedInformationContent "100" @default.
- NCIT_C126643 referenceCount "1" @default.
- NCIT_C126643 hasExactSynonym "Anti-GITR Agonistic Monoclonal Antibody INCAGN01876" @default.
- NCIT_C126643 hasExactSynonym "INCAGN 01876" @default.
- NCIT_C126643 hasExactSynonym "INCAGN 1876" @default.
- NCIT_C126643 hasExactSynonym "INCAGN-1876" @default.
- NCIT_C126643 hasExactSynonym "INCAGN01876" @default.
- NCIT_C126643 hasExactSynonym "RAGIFILIMAB" @default.
- NCIT_C126643 hasExactSynonym "Ragifilimab" @default.
- NCIT_C126643 inSubset NCIT_C116977 @default.
- NCIT_C126643 inSubset NCIT_C116978 @default.
- NCIT_C126643 inSubset NCIT_C128784 @default.
- NCIT_C126643 inSubset NCIT_C157711 @default.
- NCIT_C126643 inSubset NCIT_C157712 @default.
- NCIT_C126643 inSubset NCIT_C176424 @default.
- NCIT_C126643 inSubset NCIT_C177537 @default.
- NCIT_C126643 inSubset NCIT_C63923 @default.
- NCIT_C126643 type Class @default.
- NCIT_C126643 isDefinedBy ncit.owl @default.
- NCIT_C126643 label "Ragifilimab" @default.
- NCIT_C126643 subClassOf NCIT_C126643 @default.
- NCIT_C126643 subClassOf NCIT_C128058 @default.
- NCIT_C126643 subClassOf NCIT_C129820 @default.
- NCIT_C126643 subClassOf NCIT_C129821 @default.
- NCIT_C126643 subClassOf NCIT_C129822 @default.
- NCIT_C126643 subClassOf NCIT_C141144 @default.
- NCIT_C126643 subClassOf NCIT_C1908 @default.
- NCIT_C126643 subClassOf NCIT_C1909 @default.
- NCIT_C126643 subClassOf NCIT_C201119 @default.
- NCIT_C126643 subClassOf NCIT_C20401 @default.
- NCIT_C126643 subClassOf NCIT_C274 @default.
- NCIT_C126643 subClassOf NCIT_C307 @default.
- NCIT_C126643 subClassOf NCIT_C308 @default.