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- NCIT_C126648 IAO_0000115 "An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK), focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), with potential antineoplastic activity. Upon administration, ALK/FAK/Pyk2 inhibitor CT-707 selectively binds to and inhibits ALK , FAK and Pyk2. The inhibition leads to disruption of ALK- , FAK- and Pyk2-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK-, FAK- and Pyk2-overexpressing tumor cells. Expression of these tyrosine kinases is dysregulated in various tumor types; they play a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis." @default.
- NCIT_C126648 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126648 NCIT_NHC0 "C126648" @default.
- NCIT_C126648 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126648 NCIT_P108 "ALK/FAK/Pyk2 Inhibitor CT-707" @default.
- NCIT_C126648 NCIT_P208 "CL503764" @default.
- NCIT_C126648 NCIT_P322 "GDC" @default.
- NCIT_C126648 NCIT_P329 "779790" @default.
- NCIT_C126648 NCIT_P330 "779790" @default.
- NCIT_C126648 NCIT_P375 "ALK/FAK/Pyk2 Inhibitor CT-707" @default.
- NCIT_C126648 NCIT_P399 "779790" @default.
- NCIT_C126648 normalizedInformationContent "100" @default.
- NCIT_C126648 referenceCount "1" @default.
- NCIT_C126648 hasExactSynonym "ALK/FAK/Pyk2 Inhibitor CT-707" @default.
- NCIT_C126648 hasExactSynonym "CT 707" @default.
- NCIT_C126648 hasExactSynonym "CT-707" @default.
- NCIT_C126648 inSubset NCIT_C128784 @default.
- NCIT_C126648 inSubset NCIT_C157711 @default.
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- NCIT_C126648 inSubset NCIT_C176424 @default.
- NCIT_C126648 inSubset NCIT_C177537 @default.
- NCIT_C126648 type Class @default.
- NCIT_C126648 isDefinedBy ncit.owl @default.
- NCIT_C126648 label "ALK/FAK/Pyk2 Inhibitor CT-707" @default.
- NCIT_C126648 subClassOf NCIT_C126648 @default.
- NCIT_C126648 subClassOf NCIT_C129824 @default.
- NCIT_C126648 subClassOf NCIT_C129825 @default.
- NCIT_C126648 subClassOf NCIT_C1404 @default.
- NCIT_C126648 subClassOf NCIT_C141136 @default.
- NCIT_C126648 subClassOf NCIT_C163758 @default.
- NCIT_C126648 subClassOf NCIT_C1908 @default.
- NCIT_C126648 subClassOf NCIT_C1909 @default.
- NCIT_C126648 subClassOf NCIT_C1967 @default.
- NCIT_C126648 subClassOf NCIT_C2189 @default.
- NCIT_C126648 subClassOf NCIT_C274 @default.
- NCIT_C126648 subClassOf NCIT_C471 @default.