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- NCIT_C126687 IAO_0000115 "An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, rineterkib binds to and inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival." @default.
- NCIT_C126687 NCIT_A32 NCIT_C1909 @default.
- NCIT_C126687 NCIT_A7 NCIT_C17408 @default.
- NCIT_C126687 NCIT_A7 NCIT_C17589 @default.
- NCIT_C126687 NCIT_NHC0 "C126687" @default.
- NCIT_C126687 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126687 NCIT_P107 "Rineterkib" @default.
- NCIT_C126687 NCIT_P108 "Rineterkib" @default.
- NCIT_C126687 NCIT_P208 "CL507900" @default.
- NCIT_C126687 NCIT_P210 "1715025-32-3" @default.
- NCIT_C126687 NCIT_P319 "15KFN616FK" @default.
- NCIT_C126687 NCIT_P322 "CTRP" @default.
- NCIT_C126687 NCIT_P322 "FDA" @default.
- NCIT_C126687 NCIT_P322 "GDC" @default.
- NCIT_C126687 NCIT_P329 "780511" @default.
- NCIT_C126687 NCIT_P330 "780511" @default.
- NCIT_C126687 NCIT_P375 "ERK Inhibitor LTT462" @default.
- NCIT_C126687 NCIT_P399 "780511" @default.
- NCIT_C126687 normalizedInformationContent "100" @default.
- NCIT_C126687 referenceCount "1" @default.
- NCIT_C126687 hasExactSynonym "ERK Inhibitor LTT462" @default.
- NCIT_C126687 hasExactSynonym "LTT 462" @default.
- NCIT_C126687 hasExactSynonym "LTT462" @default.
- NCIT_C126687 hasExactSynonym "RINETERKIB" @default.
- NCIT_C126687 hasExactSynonym "Rineterkib" @default.
- NCIT_C126687 inSubset NCIT_C116977 @default.
- NCIT_C126687 inSubset NCIT_C116978 @default.
- NCIT_C126687 inSubset NCIT_C128784 @default.
- NCIT_C126687 inSubset NCIT_C157711 @default.
- NCIT_C126687 inSubset NCIT_C157712 @default.
- NCIT_C126687 inSubset NCIT_C176424 @default.
- NCIT_C126687 inSubset NCIT_C177537 @default.
- NCIT_C126687 inSubset NCIT_C63923 @default.
- NCIT_C126687 type Class @default.
- NCIT_C126687 isDefinedBy ncit.owl @default.
- NCIT_C126687 label "Rineterkib" @default.
- NCIT_C126687 subClassOf NCIT_C126687 @default.
- NCIT_C126687 subClassOf NCIT_C129824 @default.
- NCIT_C126687 subClassOf NCIT_C129825 @default.
- NCIT_C126687 subClassOf NCIT_C1404 @default.
- NCIT_C126687 subClassOf NCIT_C174048 @default.
- NCIT_C126687 subClassOf NCIT_C1908 @default.
- NCIT_C126687 subClassOf NCIT_C1909 @default.
- NCIT_C126687 subClassOf NCIT_C2189 @default.
- NCIT_C126687 subClassOf NCIT_C274 @default.
- NCIT_C126687 subClassOf NCIT_C471 @default.
- NCIT_C126687 subClassOf NCIT_C61074 @default.