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- NCIT_C126791 IAO_0000115 "A topical cream formulation containing the phosphate salt form of ruxolitinib, a bioavailable Janus-associated kinase (JAK) inhibitor, with potential immunomodulating activity. Upon topical administration of the ruxolitinib phosphate cream, ruxolitinib specifically binds to and inhibits the protein tyrosine kinases JAK 1 and 2; this inhibits signal transduction pathways of various cytokines and reduces inflammation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling pathways initiated by many cytokines and growth factors; JAK kinases are upregulated in various inflammatory and autoimmune diseases, including alopecia areata." @default.
- NCIT_C126791 NCIT_A7 NCIT_C28493 @default.
- NCIT_C126791 NCIT_A7 NCIT_C28494 @default.
- NCIT_C126791 NCIT_NHC0 "C126791" @default.
- NCIT_C126791 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C126791 NCIT_P107 "Ruxolitinib Phosphate Cream" @default.
- NCIT_C126791 NCIT_P108 "Ruxolitinib Phosphate Cream" @default.
- NCIT_C126791 NCIT_P208 "CL508203" @default.
- NCIT_C126791 NCIT_P322 "CTRP" @default.
- NCIT_C126791 normalizedInformationContent "100" @default.
- NCIT_C126791 referenceCount "1" @default.
- NCIT_C126791 hasExactSynonym "INCB018424 Phosphate Cream" @default.
- NCIT_C126791 hasExactSynonym "Ruxolitinib Phosphate Cream" @default.
- NCIT_C126791 inSubset NCIT_C116977 @default.
- NCIT_C126791 inSubset NCIT_C116978 @default.
- NCIT_C126791 type Class @default.
- NCIT_C126791 isDefinedBy ncit.owl @default.
- NCIT_C126791 label "Ruxolitinib Phosphate Cream" @default.
- NCIT_C126791 subClassOf NCIT_C126791 @default.
- NCIT_C126791 subClassOf NCIT_C1404 @default.
- NCIT_C126791 subClassOf NCIT_C1908 @default.
- NCIT_C126791 subClassOf NCIT_C1909 @default.
- NCIT_C126791 subClassOf NCIT_C1967 @default.
- NCIT_C126791 subClassOf NCIT_C471 @default.