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- NCIT_C1268 IAO_0000115 "An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis." @default.
- NCIT_C1268 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1268 NCIT_NHC0 "C1268" @default.
- NCIT_C1268 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1268 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1268 NCIT_P108 "Trofosfamide" @default.
- NCIT_C1268 NCIT_P175 "109723" @default.
- NCIT_C1268 NCIT_P207 "C0077375" @default.
- NCIT_C1268 NCIT_P210 "22089-22-1" @default.
- NCIT_C1268 NCIT_P319 "H64JRU6GJ0" @default.
- NCIT_C1268 NCIT_P322 "FDA" @default.
- NCIT_C1268 NCIT_P322 "GDC" @default.
- NCIT_C1268 NCIT_P329 "39725" @default.
- NCIT_C1268 NCIT_P330 "39725" @default.
- NCIT_C1268 NCIT_P350 "C9H18Cl3N2O2P" @default.
- NCIT_C1268 NCIT_P366 "Trofosfamide" @default.
- NCIT_C1268 NCIT_P375 "Trofosfamide" @default.
- NCIT_C1268 NCIT_P399 "39725" @default.
- NCIT_C1268 normalizedInformationContent "100" @default.
- NCIT_C1268 referenceCount "1" @default.
- NCIT_C1268 hasExactSynonym "2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide" @default.
- NCIT_C1268 hasExactSynonym "2H-1,3,2-Oxazaphosphorin-2-amine, N,N, 3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (+)-" @default.
- NCIT_C1268 hasExactSynonym "2H-1,3,2-Oxazaphosphorin-2-amine, N,N, 3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (-)-" @default.
- NCIT_C1268 hasExactSynonym "A-4828" @default.
- NCIT_C1268 hasExactSynonym "Genoxal Trofosfamida" @default.
- NCIT_C1268 hasExactSynonym "Ixoten" @default.
- NCIT_C1268 hasExactSynonym "N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide" @default.
- NCIT_C1268 hasExactSynonym "N,N,N'-tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide" @default.
- NCIT_C1268 hasExactSynonym "TROFOSFAMIDE" @default.
- NCIT_C1268 hasExactSynonym "Trilophosphamide" @default.
- NCIT_C1268 hasExactSynonym "Trofosfamid" @default.
- NCIT_C1268 hasExactSynonym "Trofosfamide" @default.
- NCIT_C1268 hasExactSynonym "Trophosphamide" @default.
- NCIT_C1268 hasExactSynonym "Z 4828" @default.
- NCIT_C1268 hasExactSynonym "Z-4828" @default.
- NCIT_C1268 inSubset NCIT_C128784 @default.
- NCIT_C1268 inSubset NCIT_C157711 @default.
- NCIT_C1268 inSubset NCIT_C157712 @default.
- NCIT_C1268 inSubset NCIT_C176424 @default.
- NCIT_C1268 inSubset NCIT_C177537 @default.
- NCIT_C1268 inSubset NCIT_C63923 @default.
- NCIT_C1268 type Class @default.
- NCIT_C1268 isDefinedBy ncit.owl @default.
- NCIT_C1268 label "Trofosfamide" @default.
- NCIT_C1268 subClassOf NCIT_C1268 @default.
- NCIT_C1268 subClassOf NCIT_C1590 @default.
- NCIT_C1268 subClassOf NCIT_C186664 @default.
- NCIT_C1268 subClassOf NCIT_C1908 @default.
- NCIT_C1268 subClassOf NCIT_C1909 @default.
- NCIT_C1268 subClassOf NCIT_C2114 @default.
- NCIT_C1268 subClassOf NCIT_C274 @default.
- NCIT_C1268 subClassOf NCIT_C2842 @default.
- NCIT_C1268 subClassOf NCIT_C697 @default.