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- NCIT_C126910 IAO_0000115 "An oligonucleotide synthesized from adenosine triphosphate (ATP) by enzymes in the 2'-5'-oligoadenylate synthase family. The production of 2'-5'-oligoadenylate is stimulated by the presence of double stranded RNA (dsRNA) and binds to inactive monomeric forms of ribonuclease L (RNase L), thereby promoting RNase L dimerization and activation. Active RNase L degrades both cellular and viral RNAs, which inhibits protein translation and leads to the abrogation of viral replication. 2'-5'-oligoadenylates play a key role in the innate immunity against viruses." @default.
- NCIT_C126910 NCIT_NHC0 "C126910" @default.
- NCIT_C126910 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C126910 NCIT_P107 "2-5-Oligoadenylate" @default.
- NCIT_C126910 NCIT_P108 "2'-5'-Oligoadenylate" @default.
- NCIT_C126910 NCIT_P207 "C0045143" @default.
- NCIT_C126910 NCIT_P322 "CTRP" @default.
- NCIT_C126910 normalizedInformationContent "100" @default.
- NCIT_C126910 referenceCount "1" @default.
- NCIT_C126910 hasExactSynonym "2'-5' Oligoadenylate" @default.
- NCIT_C126910 hasExactSynonym "2'-5'-Oligoadenylate" @default.
- NCIT_C126910 hasExactSynonym "2-5-Oligoadenylate" @default.
- NCIT_C126910 hasExactSynonym "2-5A" @default.
- NCIT_C126910 inSubset NCIT_C116977 @default.
- NCIT_C126910 inSubset NCIT_C142799 @default.
- NCIT_C126910 type Class @default.
- NCIT_C126910 isDefinedBy ncit.owl @default.
- NCIT_C126910 label "2'-5'-Oligoadenylate" @default.
- NCIT_C126910 subClassOf NCIT_C126910 @default.
- NCIT_C126910 subClassOf NCIT_C1908 @default.
- NCIT_C126910 subClassOf NCIT_C1913 @default.
- NCIT_C126910 subClassOf NCIT_C449 @default.
- NCIT_C126910 subClassOf NCIT_C706 @default.
- NCIT_C126910 subClassOf NCIT_C708 @default.
- NCIT_C126910 subClassOf NCIT_C713 @default.
- NCIT_C126910 subClassOf NCIT_C718 @default.