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- NCIT_C127116 IAO_0000115 "An orally available and selective inhibitor of the receptor tyrosine kinase AXL (UFO), with potential antineoplastic activity. Upon administration, dubermatinib targets and binds to AXL and prevents its activity. This blocks AXL-mediated signal transduction pathways and inhibits the epithelial-mesenchymal transition (EMT), which, in turn, inhibits tumor cell proliferation and migration. In addition, TP-0903 enhances chemo-sensitivity to certain other chemotherapeutic agents. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases and overexpressed by many tumor cell types, plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis." @default.
- NCIT_C127116 NCIT_A32 NCIT_C1909 @default.
- NCIT_C127116 NCIT_A7 NCIT_C17475 @default.
- NCIT_C127116 NCIT_NHC0 "C127116" @default.
- NCIT_C127116 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C127116 NCIT_P107 "Dubermatinib" @default.
- NCIT_C127116 NCIT_P108 "Dubermatinib" @default.
- NCIT_C127116 NCIT_P208 "CL507906" @default.
- NCIT_C127116 NCIT_P210 "1341200-45-0" @default.
- NCIT_C127116 NCIT_P319 "14D65TV20J" @default.
- NCIT_C127116 NCIT_P322 "CTRP" @default.
- NCIT_C127116 NCIT_P322 "FDA" @default.
- NCIT_C127116 NCIT_P322 "GDC" @default.
- NCIT_C127116 NCIT_P329 "780923" @default.
- NCIT_C127116 NCIT_P330 "780923" @default.
- NCIT_C127116 NCIT_P375 "Dubermatinib" @default.
- NCIT_C127116 NCIT_P399 "780923" @default.
- NCIT_C127116 normalizedInformationContent "100" @default.
- NCIT_C127116 referenceCount "1" @default.
- NCIT_C127116 hasExactSynonym "2-((5-Chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide" @default.
- NCIT_C127116 hasExactSynonym "DUBERMATINIB" @default.
- NCIT_C127116 hasExactSynonym "Dubermatinib" @default.
- NCIT_C127116 hasExactSynonym "TP 0903" @default.
- NCIT_C127116 hasExactSynonym "TP-0903" @default.
- NCIT_C127116 hasExactSynonym "TP0903" @default.
- NCIT_C127116 inSubset NCIT_C116977 @default.
- NCIT_C127116 inSubset NCIT_C116978 @default.
- NCIT_C127116 inSubset NCIT_C128784 @default.
- NCIT_C127116 inSubset NCIT_C157711 @default.
- NCIT_C127116 inSubset NCIT_C157712 @default.
- NCIT_C127116 inSubset NCIT_C176424 @default.
- NCIT_C127116 inSubset NCIT_C177537 @default.
- NCIT_C127116 inSubset NCIT_C63923 @default.
- NCIT_C127116 type Class @default.
- NCIT_C127116 isDefinedBy ncit.owl @default.
- NCIT_C127116 label "Dubermatinib" @default.
- NCIT_C127116 subClassOf NCIT_C127116 @default.
- NCIT_C127116 subClassOf NCIT_C129824 @default.
- NCIT_C127116 subClassOf NCIT_C129825 @default.
- NCIT_C127116 subClassOf NCIT_C1404 @default.
- NCIT_C127116 subClassOf NCIT_C1908 @default.
- NCIT_C127116 subClassOf NCIT_C1909 @default.
- NCIT_C127116 subClassOf NCIT_C1967 @default.
- NCIT_C127116 subClassOf NCIT_C2189 @default.
- NCIT_C127116 subClassOf NCIT_C274 @default.
- NCIT_C127116 subClassOf NCIT_C471 @default.